Actively Recruiting
Intra-procedural Spectral CT for Image-guided Embolization and Ablation in Interventional Oncology
Led by Palo Alto Veterans Institute for Research · Updated on 2025-12-26
30
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
P
Palo Alto Veterans Institute for Research
Lead Sponsor
C
Canon Medical Systems, USA
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to assess a new spectral CT imaging technique using Canon Medical's 4D CT system during image-guided procedures for liver and kidney cancers. The study focuses on evaluating the feasibility, image quality, and usefulness of this imaging during interventional oncology treatments such as embolization and ablation. It also explores assessing tissue changes during tumor ablation using this novel imaging technology. Participants include patients undergoing hepatic angiography mapping before trans arterial radioembolization (TARE) for liver cancer and those receiving image-guided tumor ablation with microwave ablation (MWA) or cryoablation for liver or kidney tumors. The study evaluates spectral CT images obtained during these procedures to support tumor identification, dose prediction, and ablation monitoring. During the study, participants will undergo imaging with spectral CT during their respective procedures. Researchers will assess image quality, procedural usefulness, and safety. Measurements include CT image quality at baseline, number and timing of images taken, and assessment of tissue changes. The study starts from screening, with follow-up assessments integrated into the treatment process, and continues until completion of imaging evaluations.
CONDITIONS
Brief Title
Intra-procedural Spectral CT for Image-guided Embolization and Ablation in Interventional Oncology
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Tumor located in an area without prior surgical or ablative therapy
- At least one tumor greater than 1.5 cm in greatest diameter
You will not qualify if you...
- Not eligible for the indicated procedure
- Body mass index (BMI) greater than 35
- Prior surgery in the tumor area
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of the procedure
Participants undergo hepatic angiography mapping and image acquisition using intra-arterial spectral CT prior to trans arterial radioembolization or tumor ablation procedures.
1 visit (in-person)
Duration - Post-procedure up to study completion
Participants are observed for procedural utility, safety, and image quality during and after tumor ablation or embolization procedures using spectral CT imaging.
Follow-up visits as per clinical routine
Trial Site Locations
Total: 1 location
1
VA Palo Alto Healthcare System
Palo Alto, California, United States, 94304
Actively Recruiting
Research Team
S
Sirish Kishore, MD
L
Luisa Manfredi, MPH
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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