Actively Recruiting
IVF/ICSI Outcomes in Women With Polycystic Ovary Syndrome Compared to Women Without PCOS
Led by Egymedicalpedia · Updated on 2023-10-19
156
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the outcomes of in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in women with polycystic ovary syndrome (PCOS) compared to those without PCOS. PCOS affects 5% to 10% of women of reproductive age and is a common cause of sub-fertility due to problems with ovulation. The study aims to better understand pregnancy rates and other related factors in these groups, considering the challenges in treatment such as hormonal resistance and obesity effects. The study compares pregnancy rates in two groups of women undergoing IVF/ICSI: those with PCOS and those without. Women with PCOS may have treatments including ovarian drilling or conventional ovulation induction, while all participants undergo controlled ovarian hyperstimulation and IVF/ICSI procedures. The intervention involves monitoring and comparing pregnancy outcomes at these assisted reproductive cycles. Participants will be followed from the start of IVF/ICSI treatment through to 15 days after embryo transfer, when the primary outcome of pregnancy rate is assessed. The study involves regular monitoring and evaluations during the treatment cycles. Researchers will also study other parameters within the PCOS group, such as differences between those who have had ovarian drilling and those who have not, to better understand factors affecting fertilization and pregnancy success.
CONDITIONS
Brief Title
IVF\ICSI Outcome in Women With Polycystic Ovary Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with oligo-ovulation or anovulation
- Women with clinical and/or biochemical hyperandrogenism
- Women with polycystic ovaries
- Female participants aged 20 to 35 years
You will not qualify if you...
- Presence of androgen-secreting tumors (ovarian or adrenal)
- Adult-onset congenital adrenal hyperplasia
- Thyroid diseases
- Cushing's syndrome
- Diabetes Mellitus
- Recurrent ICSI failure
- Endocrine, hematologic, or autoimmune disorders
- Non-chromosomal and genetic abnormalities
- Major uterine anomalies, severe endometriosis, hydrosalpinx, uterine fibroids, or bad surgical history
- Azospermia in partner or related factors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From baseline to 15 days after the embryo transfer day
Participants undergo IVF/ICSI procedures to evaluate pregnancy rates and other related parameters.
Multiple visits during IVF/ICSI cycle including embryo transfer and follow-up
Trial Site Locations
Total: 1 location
1
Assuit University hospitals
Asyut, Egypt
Actively Recruiting
Research Team
I
Islam Mahfouz, MSC
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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