Actively Recruiting

Phase Not Applicable
Age: 18Years - 85Years
All Genders
Healthy Volunteers
ID05425615

Probing Language Processes Using Transcranial Magnetic Stimulation

Led by Medical College of Wisconsin · Updated on 2025-05-11

135

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are studying how transcranial magnetic stimulation (TMS) affects language processing in people who have had a stroke and developed aphasia, as well as in healthy individuals. The study aims to understand changes in brain structure and specific language functions, focusing on semantic and phonological language processes and their interactions with other cognitive areas. The study uses evidence from previous brain imaging and neuropsychological research to target specific brain regions involved in language. Participants will receive active or sham repetitive or rapid TMS using a Deymed DuoMag XT-100 rTMS system with a figure-of-eight coil. The TMS will be applied to targeted brain areas related to language or control sites. The study includes active TMS, control TMS, and sham TMS groups, with treatments administered in randomized, double-blind sessions to assess short-term effects on language processing. During the study, participants will complete language tasks immediately before and after TMS sessions to measure reaction time and accuracy. These tasks help evaluate the effects of TMS on language performance. Researchers will monitor participants closely to ensure safety, and the study includes both stroke survivors with aphasia and healthy volunteers aged 18 to 85. The total participation duration varies depending on individual schedules and study procedures.

CONDITIONS

Brief Title

Language Processing and TMS

Who Can Participate

Age: 18Years - 85Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosed with left hemisphere stroke
  • Consent date at least 1 month after stroke onset
  • Right-handed
  • Fluent in English
  • 18 years of age or older
Not Eligible

You will not qualify if you...

  • Severe cognitive, auditory, or visual impairments preventing cognitive and language testing
  • Non-decisional per decisionality questionnaire or clinical assessment
  • Major untreated or unstable psychiatric disease (e.g., schizophrenia, bipolar disorder)
  • Untreated or unstable chronic medical condition
  • Presence of cardiac stimulators, pacemakers, intracardiac lines, neurostimulators, medication infusion devices, implants near the scalp or eye (e.g., cochlear implants), or metal in the body
  • Pregnancy
  • History of skull fractures or skin diseases
  • History of ongoing or unmanaged seizures or family history of epilepsy
  • Factors decreasing seizure thresholds
  • Use of pro-convulsant medications
  • Untreated sleep deprivation or insomnia
  • Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
  • History of dyslexia or other developmental learning disabilities

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Implementation

Duration - Same day

Participants receive active, control, or sham repetitive transcranial magnetic stimulation (rTMS) targeted at specific brain regions to evaluate language processing.

1 visit (in-person) including language tasks before and after TMS administration

Trial Site Locations

Total: 1 location

1

Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

Actively Recruiting

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Research Team

S

Sidney Schoenrock

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

3

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Published Research Related To This Trial

Language mapping with navigated transcranial magnetic stimulation in pediatric and adult patients undergoing epilepsy surgery: Comparison with extraoperative direct cortical stimulation.

Henri Lehtinen, Jyrki P Mäkelä, Teemu Mäkelä...

https://pubmed.ncbi.nlm.nih.gov/29881801

Seizures from transcranial magnetic stimulation 2012-2016: Results of a survey of active laboratories and clinics.

Adam J Lerner, Eric M Wassermann, Diana I Tamir

https://pubmed.ncbi.nlm.nih.gov/31104898

Clinical Utility of Transcranial Magnetic Stimulation (TMS) in the Presurgical Evaluation of Motor, Speech, and Language Functions in Young Children With Refractory Epilepsy or Brain Tumor: Preliminary Evidence.

Shalini Narayana, Savannah K Gibbs, Stephen P Fulton...

https://pubmed.ncbi.nlm.nih.gov/34093397