Actively Recruiting
Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs
Led by Florida Atlantic University · Updated on 2026-01-07
100
Participants Needed
1
Research Sites
147 weeks
Total Duration
On this page
Sponsors
F
Florida Atlantic University
Lead Sponsor
B
Baptist Health South Florida
Collaborating Sponsor
AI-Summary
What this Trial Is About
Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.
CONDITIONS
Official Title
Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Lacerations requiring one layer of sutures
- Lacerations appropriate for repair by emergency physicians
You will not qualify if you...
- Active bleeding from laceration
- Complex lacerations requiring multiple layers
- Lacerations to be repaired by a specialist service
- Patients with allergies to either diphenhydramine or lidocaine
- Laceration repairs would benefit from the use of epinephrine as an additive to the local anesthetic
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Bethesda Hospital East
Boynton Beach, Florida, United States, 33435
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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