Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs

What this Trial Is About

Researchers are evaluating the use of diphenhydramine injected locally to achieve local anesthesia compared to lidocaine 1% in patients with simple skin lacerations. The study aims to determine if diphenhydramine is not worse than lidocaine for numbing the area during laceration repair. This Phase 3 clinical trial focuses on patients presenting to the emergency department who require simple laceration repair with one layer of sutures. Participants will be randomly assigned to receive either lidocaine or diphenhydramine as a local injection before the laceration repair procedure. Both treatments are given by local infiltration, and the study is double-blinded so neither patients nor physicians know which drug is administered. The treatments are compared for their ability to reduce sensation and provide anesthesia during the repair. During the study, researchers will measure sensation reduction before injection and immediately after the laceration repair. They will also assess patient and physician satisfaction with the anesthesia right after the procedure. The study includes patients aged 18 years and older and may involve healthy volunteers. Participation involves receiving the local injection and undergoing the laceration repair while pain and anesthesia effects are carefully monitored.

Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs