Dobl

Researchers are investigating how to better select embryos for in vitro fertilization (IVF) by combining two non-invasive techniques: time-lapse imaging to study embryo development and non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) to analyze genetic status. This pilot study aims to find morphokinetic parameters that may correlate with embryo chromosomal status to improve embryo evaluation and IVF success. The study will include infertile women aged 20 to 42 undergoing IVF or ICSI treatment with niPGT-A recommended. Participants will have their embryos cultured individually in a time-lapse system from fertilization up to day 6 or 7. On day 6/7, embryos will be vitrified and the culture media collected for niPGT-A analysis. A single embryo transfer (SET) will then be performed based on the niPGT-A results, following standard clinical practice. Women who do not achieve pregnancy with one SET may undergo additional niPGT-A guided cycles while the study recruitment is ongoing. Participants will follow their regular IVF treatment schedule without extra visits required for the study. Researchers will collect clinical and personal data with privacy protections. Patients will be followed up as usual by their gynecologist, including monitoring through the 12th gestational week and, if possible, until delivery. The total participation time is estimated to be up to 11 months, including ovarian stimulation, embryo transfer, and pregnancy follow-up. The primary outcome measures will identify embryo development parameters that correlate with niPGT-A results within 6 to 7 days of embryo culture.