Geraardsbergen

Researchers are evaluating whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience sudden out-of-hospital cardiac arrest. PEEP is applied during ventilation to keep airways open, which may enhance oxygen levels. This Phase 3 trial aims to determine if PEEP helps restart the heart more effectively, improves survival rates, and leads to better neurological outcomes compared to standard CPR without PEEP. Participants will be randomly assigned to one of two groups: one receiving CPR with a disposable PEEP valve set at 5 cm H2O and the other receiving standard CPR without PEEP. Both groups will be ventilated using an adult resuscitation bag with a pressure relief valve set at 40 cm H2O. Emergency medical teams trained in advanced life support will perform intubation and ventilation during resuscitation efforts. Custom sensors will measure airflow and airway pressure to monitor the ventilation process. During the study, researchers will collect data on the return of spontaneous circulation (ROSC) on day one, survival to hospital admission and discharge, and neurological outcomes at discharge. Safety will be closely monitored, including potential side effects such as increased chest pressure or lung injuries. The study results will help determine if PEEP should be included in standard CPR guidelines for out-of-hospital cardiac arrest patients.