Knokke Heist

This clinical trial focuses on adults who experience out-of-hospital cardiac arrest, where the heart suddenly stops beating. Researchers are studying whether using Positive End-Expiratory Pressure PEEP during cardiopulmonary resuscitation CPR improves outcomes such as restarting the heart, survival rates, and neurological function compared to standard CPR without PEEP. This study is a phase 3 randomized trial addressing a gap in knowledge about ventilation during CPR and its impact on patient outcomes. Participants are randomly assigned to one of two groups one receives CPR with PEEP set at 5 cm H2O using an adult resuscitation bag with a disposable PEEP valve, and the other receives standard CPR without PEEP using the same type of resuscitation bag but without the PEEP valve. Ventilation and airway pressures are monitored with specialized sensors during resuscitation by advanced life support medical teams. The study evaluates both effectiveness and safety, including potential side effects like increased chest pressure or lung injury. During the study, participants return of spontaneous circulation ROSC is measured as the primary outcome. Secondary outcomes include survival to hospital admission and discharge, 30- and 90-day survival, and neurological function at discharge. Data on CPR quality and physiological measurements are collected. The trial follows participants from enrollment through hospital discharge or death, with detailed monitoring of outcomes and safety to guide future CPR guidelines.

This research aims to evaluate the effects of real-time ventilation feedback on ventilation rate and tidal volume during cardiac arrest. Patients undergoing out-of-hospital cardiopulmonary resuscitation are studied to compare ventilation delivered without feedback to ventilation with feedback. The trial investigates whether showing real-time data to the user influences ventilation performance during manual resuscitation. Patients are intubated and ventilated using a manual resuscitator connected to a flowsensor. Initially, ventilation is performed without feedback while the sensor records ventilation data. In the subsequent cycle, real-time ventilation frequency and volume are displayed on a screen to inform the user. This feedback device is used to assess changes in ventilation delivery. Data collected during both phases is saved automatically. Participants are involved during two ventilation cycles, first without feedback and then with feedback from the device. Researchers measure delivered ventilation frequency and volume over two minutes each. The study collects and analyzes ventilation data to understand the impact of feedback on resuscitation quality. The trial is sponsored by University Hospital, Ghent and includes adult patients experiencing cardiac arrest.