Sint Martens Latem

Researchers are comparing two surgical techniques for placing a total knee replacement in patients with advanced knee osteoarthritis. The study evaluates image-based robotic total knee arthroplasty and imageless augmented reality-assisted total knee arthroplasty. Both techniques aim to improve the accuracy of prosthesis placement using additional angle and axis information obtained during surgery. This comparison seeks to determine if the two methods provide equivalent results and optimize patient care. Participants will undergo one of two procedures the Skywalker Robotics Assisted TKA using the Evolution Medial Pivot Knee or the Pixee Knee augmented reality-assisted TKA using the same knee prosthesis. Both are established surgical methods that use technology to guide precise implant positioning. The study randomly assigns patients to either surgical technique to assess and compare their effectiveness. During the study, researchers will monitor implant alignment and positioning via full-leg standing X-rays for one year after surgery. They will also assess safety, clinical outcomes, and activity levels over a two-year follow-up period. Participants will have regular assessments to track recovery, implant function, and overall knee performance, contributing to a better understanding of these assistive technologies in knee replacement surgery.

Researchers are investigating how well and safely Eloralintide LY3841136 works in adults who are overweight or obese and suffer from osteoarthritis pain in the knee. This study supports two independent phase 3 trials under a master protocol, focusing on improving knee osteoarthritis symptoms and body weight management in this population. Participants will receive either Eloralintide or a placebo by subcutaneous injection once weekly. The study follows a randomized, double-blind, parallel design with two separate arms for each independent study. Treatment and observation will last approximately 75 weeks, including the screening period. During the study, participants will undergo various assessments including measurements of body weight, knee pain using the Western Ontario and McMaster Universities Osteoarthritis Index WOMAC pain subscale, blood pressure, physical function, inflammation markers, and metabolic parameters. Researchers will also track medication use, walk test performance, and other health-related quality of life measures over time to evaluate the effects and safety of Eloralintide.