Charlottetown

Researchers are evaluating the use of intravenous thrombolysis IVT with tenecteplase for patients who have suffered an acute ischemic stroke AIS. This study aims to compare the effectiveness of standard-dose tenecteplase 0.25 mgkg body weight against a lower dose 0.18 mgkg and also to assess scenarios where no tenecteplase is given upfront, particularly in patients recently taking direct oral anticoagulants DOACs or those planned for emergency endovascular thrombectomy EVT. The trial seeks to provide clearer guidance on dosing and treatment choices, especially for specific patient groups like the elderly or those with other health conditions. Participants are randomly assigned to one of three groups receiving standard-dose tenecteplase, low-dose tenecteplase, or no tenecteplase upfront if eligible for EVT or recently taking DOACs. Tenecteplase is administered as a single intravenous bolus shortly after randomization. The study design is open-label with blinded endpoint assessment and follows patients for 90 days after treatment or until death. During the study, patients will have their functional outcomes measured using the modified Rankin Scale at 90 days, with assessments done by telephone. Researchers will also track mortality, quality of life, serious adverse events, intracranial hemorrhages, and imaging outcomes related to brain infarcts and reperfusion success after EVT. Hospital stay length and ambulatory status at discharge will be recorded. Safety monitoring occurs up to 36 hours post-treatment, with imaging reviewed by blinded experts. The total participant involvement lasts up to 90 days from enrollment.

This trial studies the effects of a single 40-minute infrared sauna session on blood sugar control in adults aged 30 to 55 who are at risk for metabolic problems like obesity. Researchers want to see if using a sauna before a meal can lower blood sugar spikes after eating and improve overall glucose control throughout the day. The study uses a randomized crossover design, comparing sauna sessions to resting sessions. Participants will first complete a sauna familiarization with two 20-minute infrared sauna exposures at 175F 79C. Then, they will undergo two lab visits one involving two 20-minute sauna sessions separated by a 5-minute break, and one with two 20-minute seated resting periods, also separated by a 5-minute break. Visits are spaced at least 72 hours apart. After each session, participants will consume standardized meals at home and wear a continuous glucose monitor CGM to track blood sugar. During visits, participants fast overnight and have blood pressure, heart rate, and body temperature measured before and after the sessions. Meals including breakfast, lunch, dinner, and a bedtime snack are provided and kept consistent across visits. Researchers will monitor glucose responses after meals and over 24 hours, along with other physiological measures. The trial ends after these assessments, with participation lasting a few weeks including familiarization and two experimental visits.

Researchers are evaluating the Prostate Cancer Patient Empowerment Program PC-PEP in men diagnosed with prostate cancer to improve mental health and quality of life. The study focuses on addressing side effects from common treatments like surgery and radiation, which often cause urinary incontinence, sexual dysfunction, and reduced physical function. It aims to support mental health and overall well-being in men undergoing curative treatment for prostate cancer. The PC-PEP is a six-month home-based program that includes aerobic and strength training exercises, pelvic floor muscle training, meditation, social connection, and healthy lifestyle practices. Participants receive daily reminders via text or email to encourage engagement, and they are paired with peers for social support. The program also involves educational materials delivered through multimedia and in-person sessions to teach life skills and habits that may reduce treatment-related side effects. Participants will be involved in regular assessments including online surveys at the start, 6, 12, and 24 months, and weekly compliance surveys during the program. Researchers will measure mental health as the primary outcome and other factors such as physical and mental quality of life, urinary and sexual function, sleep quality, diet, anxiety symptoms, and relationship satisfaction. The study also monitors health care utilization and self-efficacy over a two-year period.