Jiangmen

Liver failure is a serious condition involving severe liver damage due to causes like viral infections, alcohol use, drugs, and blood flow problems. It often leads to damage in other organs and has a high risk of death. This research aims to create a detailed real-world database of hospitalized liver failure patients in China to study their clinical features, infections, muscle loss impact, and improve treatments such as antiviral drugs and artificial liver support. The knowledge gained will support future studies focusing on infections, organ failure in late-stage liver disease, and early warning signs in critically ill patients. The study collects data on three types of liver failure based on timing and liver disease history: acute liver failure with rapid onset and severe brain effects within 2 weeks; subacute liver failure with symptoms appearing between 2 and 26 weeks; and acute-on-chronic liver failure, which occurs suddenly in patients with existing chronic liver disease. Data is gathered through a collaborative network using an electronic clinical system to capture patient information and treatment details. Participants will be monitored for outcomes including survival rates at 28 and 90 days. The study involves detailed data collection on symptoms, lab tests like liver enzymes and blood clotting measures, and clinical status. Researchers will analyze these data to understand disease progression and treatment effects. Safety and clinical condition assessments are included to guide better management of liver failure over time.