Popayan

Researchers are conducting an international, multicenter observational study to understand acute kidney injury requiring renal replacement therapy AKI-RRT in Latin American countries. The study focuses on the epidemiology, outcomes, and care processes for patients with AKI-RRT, comparing variations across different countries and examining factors such as demographics, clinical profiles, and socioeconomic status that may influence patient outcomes. The aim is to establish a comprehensive database to support clinical research and improve understanding of AKI-RRT in this region. The study observes critically ill adult patients admitted to intensive care units ICUs who are undergoing any form of renal replacement therapy. It collects detailed clinical, laboratory, treatment, and outcome data without assigning treatments, as it is observational. Patients are followed from enrollment through hospital discharge or up to 90 days, including ICU stay and 90-day post-ICU follow-up to track mortality, renal recovery, and complications related to renal replacement therapy. Participants involvement includes monitoring during ICU and hospital stays with data collected on mortality rates, length of stay, renal function recovery, dependence on renal replacement therapy, and complications such as infections or anticoagulation issues. The primary outcome measured is in-hospital mortality, with secondary outcomes covering ICU mortality, 90-day mortality, length of stay, recovery, and procedural complications. This study spans from enrollment until 90 days after ICU admission, providing extensive observational data on AKI-RRT in Latin America.

Researchers are studying adults with acute kidney injury AKI who are critically ill and receiving continuous renal replacement therapy CRRT. The study aims to understand how well patients tolerate fluid removal through net ultrafiltration UFNET during CRRT. This is an observational study focusing on how changes in heart function, blood flow, tissue perfusion, and congestion-related signs might predict intolerance to fluid removal before severe low blood pressure occurs. Participants are critically ill adults receiving CRRT with UFNET prescribed by their clinical care team. The study does not change or assign treatments but monitors patients using multiple methods. These include clinical assessments, hemodynamic monitoring, cardiac ultrasound, venous congestion evaluation, peripheral perfusion measurements, biochemical tests, and fluid balance tracking. Data is collected before and during the early phase of fluid removal, with additional recordings if signs of intolerance appear. Participants will be assessed at scheduled times using standard medical records, bedside monitors, laboratory results, and ultrasound exams. The study will track the development of ultrafiltration intolerance within 24 hours of UFNET start. Researchers will analyze various physiological and clinical factors to identify predictors of intolerance. The study may help tailor fluid removal strategies and improve CRRT safety in critically ill patients with AKI. Participation includes monitoring without altering usual care, and data will be kept confidential and anonymized.