Knin

Researchers are evaluating the effectiveness of two types of ultrasound-guided perineural injections to treat carpal tunnel syndrome (CTS), a condition affecting the median nerve in the wrist. This prospective, randomized, double-blinded study compares 5% dextrose injection alone versus 5% dextrose combined with methylprednisolone, a steroid medication. The study aims to determine differences between these treatments in pain relief, symptom severity, hand function, nerve size, and quality of life over six months following the intervention. Participants will be randomly assigned to one of two groups. One group will receive a single 4 ml ultrasound-guided injection of 5% dextrose into the carpal tunnel, while the other group will receive a single ultrasound-guided injection of 3 ml 5% dextrose combined with 1 ml of 40 mg/ml methylprednisolone acetate. Injections are administered via the ulnar approach. Blinding will be maintained for participants, clinicians giving the injections, and assessors evaluating the outcomes, with only the nurse preparing the medication aware of group assignments. During the study, participants will undergo assessments before the injection and at 4, 12, and 24 weeks afterward. Evaluations include measuring pain intensity, symptom severity, hand grip strength, median nerve cross-sectional area via ultrasound, and overall quality of life. Pain intensity at 4 weeks post-injection is the primary outcome. Participants may use acetaminophen or tramadol occasionally for pain relief, but other treatments like physical therapy or wrist splints are not allowed. The total study duration covers a six-month follow-up period to monitor treatment effects and safety.