Milovice Nad Labem 3

Researchers are investigating whether low serum creatinine levels measured upon admission to a post-ICU care unit can predict the need for prolonged mechanical ventilation and difficulties in weaning patients off ventilatory support. The study also evaluates if giving creatine as a dietary supplement to patients with low serum creatinine can shorten the time they require ventilatory support and improve their overall outcomes. This research focuses on critically ill adults recovering from intensive care, where muscle loss and decreased creatine production are common, potentially affecting patient recovery. The study includes three groups: one receiving creatine supplements, another receiving a placebo (polydextrose), and a control group receiving standard care without supplements. The creatine or placebo is administered either orally or via a nasogastric tube. For the first seven days after enrollment, participants receive two doses of 5 grams daily, followed by one 5-gram dose daily from days 8 to 21. This design allows comparison of outcomes between those supplemented with creatine and those who are not. Participants will be monitored for ventilator-free hours over 21 days, with researchers assessing the duration of ventilatory support needed. Evaluations include serum creatinine levels, patient outcomes, and weaning success from mechanical ventilation. The study aims to clarify whether creatine supplementation benefits patients with low serum creatinine admitted to post-ICU care, potentially influencing recovery and survival. Total participation includes 21 days of intervention with ongoing observation of respiratory support needs.