Milovice Nad Labem 3

Researchers are studying whether low serum creatinine levels at admission to a post-ICU care unit can predict the need for longer ventilatory support in critically ill adults. The study also explores if giving creatine supplements to patients with low creatinine levels can shorten the time they need ventilators and improve their overall outcomes. This research addresses muscle loss and its effects after a critical illness stay in the ICU. The study includes three groups of adult patients admitted to a post-ICU care unit. One group with normal creatinine levels will receive standard care without any intervention. Patients with low creatinine levels will be randomly assigned to receive either creatine supplements or a placebo, both given orally or via a tube for up to 21 days. The creatine dosage is 10 grams daily for the first 7 days and 5 grams daily from days 8 to 21. Participants will be monitored for 21 days to track ventilator-free hours, infections, muscle strength, cognitive status, and ability to care for themselves. The study will assess tolerance to creatine and compare outcomes between groups. Careful observation and data collection will help determine the relationship between creatinine levels, creatine supplementation, and weaning from mechanical ventilation.