Maadi

Renal cell carcinoma (RCC) is a common cancer of the urinary system, representing 2-3% of all cancers. Open nephrectomy is a standard surgery for RCC but often causes severe postoperative pain, which can lead to breathing difficulties, lung problems, and longer hospital stays. Pain after surgery results from inflammation, nerve activation, and muscle spasms. While pain usually improves during recovery, some patients develop chronic postsurgical pain lasting at least two months. Opioids and epidural analgesia are common but have side effects, so safer pain control methods are needed. This research is comparing two ultrasound-guided nerve block techniques for pain relief after open nephrectomy: the external oblique intercostal plane block (EOIPB) and the posterior transversus abdominis plane (TAP) block. EOIPB targets nerves from T6 to T10 and can be done while lying on the back, offering better midline pain relief than some other blocks. The posterior TAP block provides pain relief from T7 to T12 by numbing specific nerve branches. Both are studied as part of multimodal pain control. Participants will receive one of these blocks during surgery under general anesthesia. Researchers will monitor postoperative morphine use within the first 24 hours as the main measure of pain relief. The study includes adult patients with renal carcinoma scheduled for open nephrectomy. Safety, effectiveness of pain control, and other outcomes will be assessed during the hospital stay, focusing on how well these blocks reduce opioid use after surgery.

Researchers are evaluating the effectiveness of intracapsular injections of Terlipressin versus Carbetocin in women undergoing abdominal laparoscopic myomectomy to reduce blood loss and improve hemoglobin levels. This study is a prospective, comparative, double-blinded randomized placebo-controlled trial conducted at multiple centers. The aim is to assess the impact of these injections on blood loss during surgery, operative time, and potential side effects in women with myoma. Participants will be randomly assigned into one of three groups: one receiving an intramyometrial injection of Terlipressin, another receiving Carbetocin, and a third receiving a saline injection as a placebo. The injections are administered during the laparoscopic myomectomy procedure, and the study follows a strict protocol to ensure blinding and randomization. During the study, medical records will be reviewed, and blood tests and ultrasounds will be performed. Researchers will monitor changes in hemoglobin levels and blood loss within 12 hours after the procedure. Data will be collected and analyzed in aggregate without revealing individual identities. This trial includes women aged 16 to 45 undergoing laparoscopic myomectomy with specific medical criteria and will track safety and efficacy outcomes throughout the surgical and immediate postoperative periods.

Researchers are evaluating the effects of intramyometrial injections of Terlipressin versus Carbetocin on hemoglobin levels and blood loss in women undergoing open myomectomy without using haemostatic tourniquets. This prospective, double-blinded, randomized trial aims to provide clear clinical evidence to guide the best practice for managing blood loss during surgery. The study also includes a control group receiving saline injections for comparison and involves women diagnosed with myoma who meet specific medical criteria. The study consists of three groups: one receiving Terlipressin injections, another receiving Carbetocin injections, and a third receiving saline injections, all administered during the open myomectomy procedure without using mechanical tourniquets. Participants will be randomly assigned to one of these three arms in equal proportions. The interventions focus on assessing the impact of these agents on reducing blood loss and maintaining hemoglobin levels during surgery. Participants will undergo blood tests and ultrasounds as part of the study assessments. Researchers will measure the volume of blood lost during surgery within a 12-hour period to compare the effectiveness of each injection. Medical records will be reviewed with informed consent, and data will be anonymized. The study is conducted across multiple centers, and participant involvement includes monitoring blood loss, hemoglobin levels, and related outcomes to inform better surgical practices.