Maadi

Renal cell carcinoma RCC is a common type of cancer affecting the genitourinary tract, making up 2-3% of all cancers. Open nephrectomy is a standard surgery for RCC but often causes significant postoperative pain, which can lead to breathing difficulties, lung problems, and longer hospital stays. While most patients experience pain relief during recovery, some develop chronic pain lasting at least two months after surgery. Traditional pain treatments like opioids and epidural analgesia have side effects and risks, prompting research into safer options such as ultrasound-guided nerve blocks. This study compares two ultrasound-guided pain relief techniques used during open nephrectomy the external oblique intercostal plane block EOIPB and the posterior transversus abdominis plane TAP block. EOIPB targets specific nerves in the front and side of the abdomen and can be performed while the patient lies on their back, potentially providing better midline pain relief. The posterior TAP block numbs nerve branches from the mid to lower abdomen. Both techniques are evaluated for their effectiveness in controlling post-surgical pain under general anesthesia. Participants will be randomly assigned to receive either the EOIPB or posterior TAP block during surgery. Researchers will monitor pain levels by measuring the amount of morphine used in the first 24 hours after surgery. The study uses a triple-blinded design to ensure unbiased results. Conducted by Cairo University, this trial aims to find which block provides better pain control after open nephrectomy, helping improve recovery and reduce opioid use.

Researchers are evaluating the effects of intramyometrial injections of Terlipressin versus Carbetocin on hemoglobin levels and blood loss in women undergoing open myomectomy without the use of haemostatic tourniquets. This prospective, comparative, double-blinded randomized placebo-controlled trial aims to provide clinical evidence to guide best practices and improve outcomes for women with myoma undergoing this surgery. The study is conducted at multiple centers and includes women with relevant myoma-related symptoms. Participants are randomly assigned to one of three groups receiving intramyometrial Terlipressin, Carbetocin, or a saline injection during their open myomectomy procedure. The study excludes the use of mechanical tourniquets in all groups. The treatments are administered during surgery, and the groups are balanced with a 111 allocation ratio using computer-generated randomization. During the study, women will have their blood loss measured during surgery and hemoglobin levels monitored before and after the operation. Additional assessments include operative time and pain severity using a visual analog scale within 24 hours post-surgery. Blood tests and ultrasound are used for evaluations, and all data are collected confidentially. Safety and outcomes are monitored closely, with participation lasting through the immediate perioperative period up to 24 hours after surgery.