Actively Recruiting
Analgesic Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Posterior Transversus Abdominis Plane Block in Patients Undergoing Open Nephrectomy
Led by Cairo University · Updated on 2026-06-01
56
Participants Needed
2
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Renal cell carcinoma (RCC) is a common type of cancer affecting the genitourinary tract, making up 2-3% of all cancers. Open nephrectomy is a standard surgery for RCC but often causes significant postoperative pain, which can lead to breathing difficulties, lung problems, and longer hospital stays. While most patients experience pain relief during recovery, some develop chronic pain lasting at least two months after surgery. Traditional pain treatments like opioids and epidural analgesia have side effects and risks, prompting research into safer options such as ultrasound-guided nerve blocks. This study compares two ultrasound-guided pain relief techniques used during open nephrectomy: the external oblique intercostal plane block (EOIPB) and the posterior transversus abdominis plane (TAP) block. EOIPB targets specific nerves in the front and side of the abdomen and can be performed while the patient lies on their back, potentially providing better midline pain relief. The posterior TAP block numbs nerve branches from the mid to lower abdomen. Both techniques are evaluated for their effectiveness in controlling post-surgical pain under general anesthesia. Participants will be randomly assigned to receive either the EOIPB or posterior TAP block during surgery. Researchers will monitor pain levels by measuring the amount of morphine used in the first 24 hours after surgery. The study uses a triple-blinded design to ensure unbiased results. Conducted by Cairo University, this trial aims to find which block provides better pain control after open nephrectomy, helping improve recovery and reduce opioid use.
CONDITIONS
Brief Title
Analgesic Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Posterior Transversus Abdominis Plane Block in Patients Undergoing Open Nephrectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with renal carcinoma and scheduled for open nephrectomy under general anesthesia
- ASA physical status class II or III
- Age between 18 and 70 years
- Body mass index (BMI) less than 40 kg/m2
You will not qualify if you...
- Patient refusal to participate
- Liver or kidney failure
- Unstable heart or lung disease
- History of psychiatric or cognitive disorders
- Known allergy or contraindication to the study drugs
- Regular use of opioid pain medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 24 hours post-procedure
Participants undergo either an ultrasound-guided external oblique intercostal plane block or a posterior transversus abdominis plane block during open nephrectomy surgery.
1 surgical procedure and postoperative monitoring
Trial Site Locations
Total: 2 locations
1
Abeer Ahmed Mohamed
Maadi, Cairo Governorate, Egypt, 11728
Completed
2
Kasr Alainy Faculty of Medicine - Cairo university
Cairo, Egypt, 00225
Actively Recruiting
Research Team
A
Abeer A Mohamed
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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