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Researchers are evaluating tozorakimab as an additional treatment to standard care in adults hospitalized with viral lung infection who need supplemental oxygen. The study aims to determine if tozorakimab can help prevent death or the need for invasive mechanical ventilation or extracorporeal membrane oxygenation. This Phase III trial involves a large group of participants to assess the safety and effectiveness of this approach. Participants are randomly assigned to one of two groups one group receives a single intravenous dose of tozorakimab on the first day, while the other group receives a matching placebo. The study uses a double-blind design, meaning neither participants nor researchers know which treatment is given. This helps ensure unbiased results. The treatments are given once, and participants continue to receive standard care during the trial. During the study, participants are closely monitored and evaluated up to 60 days after treatment. Researchers track important outcomes such as death rates, progression to invasive ventilation, days alive outside intensive care, and oxygen use. They also assess clinical progression using a World Health Organization scale and monitor for any anti-drug antibodies. The trial lasts until November 2027, with multiple assessments throughout to understand the treatments impact and safety.

This research aims to compare the accuracy of two types of surgical guides used to place zygomatic implants in patients with severe bone loss in the upper jaw. Zygomatic implants are longer than regular dental implants and are fixed in the cheekbone, which generally has enough bone to support them. The study focuses on patients with severely atrophic maxilla who need these special implants due to significant bone loss. The main goal is to determine whether fully metallic surgical guides or resin-based guides improve the precision of implant placement. Participants will receive zygomatic implants on both sides of the upper jaw during surgery. On one side, the implant will be placed using a fully metallic surgical guide made of nickel with CADCAM technology. On the other side, the implant will be placed using a resin surgical guide made from biocompatible 3D-printed material. Before surgery, patients will undergo a CT scan and digital impressions or planning to create these guides. This allows direct comparison of the two guide types within the same patient. During the study, patients will have clinical examinations and CT scans before and after surgery to plan and verify implant placement. Researchers will measure the difference between planned and actual implant positions to assess accuracy. Additional outcomes include implant stability, surgical time, and any complications during surgery. Participation involves follow-up visits and signing informed consent, with the study lasting through the implant placement and evaluation periods.

Researchers are investigating how frontal and axial back asymmetry relates to self-perceived body image in adolescents with idiopathic scoliosis. This observational study focuses on patients aged 11 to 18 years diagnosed with moderate scoliosis, characterized by a Cobb angle between 25 and 45 degrees, and a major thoracic curve. The study aims to understand the connection between physical spinal deformities and body image satisfaction using specific assessment tools. Participants will undergo evaluation using BACKSCNR, a non-invasive device that measures deviations in frontal and axial back asymmetry through optical scanning technology without radiation. Self-body image will be assessed with the Trunk Appearance Perception Scale TAPS questionnaire, which evaluates participants satisfaction with their body image. This study involves one group of adolescents with idiopathic scoliosis. During the study, researchers will measure frontal plane back asymmetry, axial trunk deviations, and self-perceived body image at the start of participation. The assessments help to understand how spinal shape variations relate to participants body image. The total study duration and follow-up details are not specified, but the primary measurements occur at baseline. The study is sponsored by Al Hayah University In Cairo and is scheduled to start in September 2025.

This research focuses on patients who have an atrophied posterior maxilla and need dental implants. It compares two methods of maxillary sinus floor elevation and augmentation one using a 11 mixture of the patients own bone autogenous bone with deproteinized bovine bone particulate, and the other using deproteinized bovine bone particulate alone. The goal is to evaluate bone height and volume changes after these procedures. The study involves two phases. In the first phase, patients undergo surgery under local anesthesia where a lateral window is created in the maxillary bone and the sinus membrane is carefully lifted. Depending on the group, either the bone mixture or bovine bone alone is placed into the sinus cavity, covered with a collagen membrane, and the flap is sutured. In the second phase, six months later, delayed implant placement is performed, and a core biopsy is taken from the implant site for histological analysis. The flap is then closed with sutures. Participants will have preoperative CBCT imaging to assess the sinus anatomy and bone quality. Follow-up includes assessment of bone height changes at nine months. The study monitors bone volume changes as a secondary outcome. All surgical procedures are performed by a single experienced oral surgeon to ensure consistency. The total participation includes initial surgery, delayed implant placement with biopsy, and imaging assessments over several months.

Researchers are studying the connection between the thickness of deep scar tissue and ongoing weakness in the calf muscles of adults who have recovered from tennis leg, a common calf muscle injury caused by a partial tear in the gastrocnemius muscle. This observational study focuses on adults aged 18 to 40 years with a confirmed unilateral calf muscle tear at least 3 months prior, who have returned to their regular daily activities. The goal is to understand how scar tissue affects long-term muscle strength and help improve rehabilitation and return-to-activity decisions. The study uses B-mode diagnostic ultrasound to measure the thickness of scar tissue at the muscle-tendon junction in both injured and uninjured legs. It also employs an isokinetic dynamometer to measure the eccentric strength of the calf muscles at two different speeds. Each participant serves as their own control by comparing the injured leg to the uninjured leg. No treatment is provided, and all assessments take place during a single study visit. Participants will complete one study visit where ultrasound imaging and strength tests will be done to assess scar tissue and muscle function. Additional tests include endurance of a single-leg heel raise, time to fatigue during repeated plantar flexion, and ankle range of motion. The main outcomes measured are the percentage strength deficit and scar tissue thickness. These results aim to help clinicians better predict recovery and guide rehabilitation for tennis leg patients.

Atypical hemolytic uremic syndrome aHUS is a rare and serious disease that can occur at any age, characterized by damage to small blood vessels and often impacting the kidneys. This condition is linked to problems with the complement system, sometimes caused by genetic mutations or antibodies. The disease has a high mortality rate and can lead to kidney failure requiring dialysis. Since specific treatments like complement inhibitors are not yet available in Egypt, this study focuses on understanding the impact of aHUS on patients in Egyptian hospitals, aiming to improve diagnosis and management. This research is an observational, retrospective cohort study conducted across multiple centers in Egypt. It aims to collect information from patient records dating from 2010 to 2023, including demographic and clinical data, disease progression, and treatment outcomes. The study will estimate how common aHUS is among patients with thrombotic microangiopathy TMA and examine real-world treatment patterns and results, as no prior data exists from the country. Participants medical records will be reviewed over a 10-year period to gather detailed information about their aHUS diagnosis, clinical characteristics, and long-term complications. The study will assess treatment outcomes and patterns during this time. Since this is an observational study, there are no interventions or treatments assigned by the study. The total duration for outcome measurement is 10 years, allowing for a comprehensive understanding of disease burden and management in Egypt.