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Researchers are evaluating the effect of tozorakimab, added to standard care, in adults hospitalized with viral lung infection who need supplemental oxygen. The study focuses on preventing death or progression to invasive mechanical ventilation or extracorporeal membrane oxygenation by day 28. This is a Phase III, multicenter, randomized, double-blind trial comparing tozorakimab to placebo in patients with viral lung infection causing acute respiratory failure. Participants will receive a single intravenous dose of either tozorakimab or a matching placebo on the first day of the study. Both groups continue to receive standard care for their viral lung infection. The study is designed to assess the safety and efficacy of tozorakimab as an add-on therapy in this patient population. Throughout the study, researchers will monitor participants for survival and the need for invasive mechanical ventilation or ECMO up to 28 days after treatment. The main outcome measured is the proportion of patients who die or require mechanical ventilation or ECMO by day 28. Participants will be closely observed during hospitalization, with data collected on their respiratory status and treatment outcomes to evaluate the study drug's impact and safety.

Some patients experience severe bone loss in the upper jaw, making it difficult to place regular dental implants. This research evaluates the accuracy of placing special zygomatic implants, which are longer and anchored in the cheekbone, in patients with this condition. The study compares two types of surgical guides—fully metallic and resin-based—to see which better helps surgeons place implants precisely. Before surgery, patients will have a clinical examination and CT scan to plan implant positions. During the operation, each patient will receive zygomatic implants on both sides of the upper jaw. One side will use a resin surgical guide made from a strong plastic material created with 3D printing, while the other side will use a metallic guide made of nickel designed with CAD/CAM technology. This allows direct comparison of the two guides in the same patient. Participants will have CT scans before and after surgery to assess how closely the implants match the planned positions, measuring placement accuracy. Researchers will monitor the implants' placement accuracy from enrollment through the 4-week surgery period. Patients will be fully informed and consent to participate voluntarily. The study aims to determine if metallic or resin surgical guides provide better support during zygomatic implant placement in severely atrophic maxilla cases.

Researchers are examining the link between back asymmetry in the frontal and axial planes and how adolescents with idiopathic scoliosis perceive their own body image. This study focuses on patients aged 11 to 18 years diagnosed by an orthopedic surgeon with adolescent idiopathic scoliosis who have moderate curvature of the spine and specific body mass index ranges. The goal is to understand how spinal deformities relate to self-image and satisfaction using a specialized questionnaire. Participants will have their back asymmetry measured using the BACKSCNR device, a non-invasive tool that uses optical scanning to capture a three-dimensional shape of the back without radiation. This measurement focuses on frontal and axial deviations of the back in patients with moderate scoliosis and major thoracic curves. During the study, participants will undergo assessments including measurements of frontal plane back asymmetry, axial trunk deviations, and self-perceived body image using the TAPS questionnaire. These evaluations occur at baseline to establish relationships between physical spinal deformities and self-image in adolescent patients with scoliosis.

Researchers are studying the connection between the thickness of scar tissue inside the calf muscle and ongoing weakness in patients who have recovered from "tennis leg," a common injury caused by a partial tear in the inner calf muscle where it meets the tendon. Although most patients return to normal daily activities after healing, many still have hidden muscle weakness, especially when the muscle lengthens under load during activities like walking downhill, running, or landing from a jump. This study aims to better understand how scar tissue affects long-term muscle strength in these patients. The study uses two diagnostic tests: B-mode diagnostic ultrasound to measure the thickness of deep scar tissue at the muscle-tendon junction of the medial gastrocnemius muscle, and isokinetic dynamometry to assess the eccentric (lengthening) strength of the calf muscles at different speeds. Both injured and uninjured legs are measured for comparison. These tests are performed once during a single study visit by trained professionals, with no treatment or intervention given as part of the study. Participants are adults aged 18 to 40 years who have had a confirmed tear in one calf muscle at least three months prior and have returned to normal daily activities. During the visit, ultrasound imaging and strength testing are done to measure scar tissue thickness and muscle strength deficits. The main outcomes include the percentage strength deficit between legs and the thickness of deep scar tissue. This information may help improve rehabilitation and decisions about returning to physical activities after tennis leg injury.

Atypical hemolytic uremic syndrome (aHUS) is a rare and serious disease that can affect people of any age. It is a form of thrombotic microangiopathy caused by problems in the complement system, mainly impacting the kidneys. This condition can be inherited or occur sporadically, with many patients having specific genetic mutations or antibodies. aHUS carries a high risk of death and kidney failure, often requiring dialysis, and patients face a significant chance of disease relapse, making ongoing care vital. This research is an observational, retrospective study conducted across multiple centers in Egypt. It aims to collect and describe demographic and clinical data on patients diagnosed with aHUS from 2010 to 2023. Since complement inhibitor therapies are not available in Egypt, the study also evaluates the real-world outcomes of the treatments currently used. The goal is to better understand how aHUS affects patients in Egyptian hospitals to support earlier diagnosis and improved management. Participants will be identified from hospital records of patients aged one month or older diagnosed with thrombotic microangiopathy during the study period. Researchers will gather information on patient characteristics, disease progression, and long-term complications over ten years. The study will also estimate how common aHUS is among all TMA patients and monitor clinical outcomes to improve knowledge of aHUS treatment effects and patient health over time.