Mikkeli

Carpal tunnel syndrome is a common condition causing pain, numbness, and tingling in the fingers, often worse at night. This trial evaluates the effects of night-time and full-time wrist splinting compared to no treatment in people with carpal tunnel syndrome. It also aims to find which groups might benefit most from splinting and whether responding well to splinting reduces the need for surgery. Participants will use a neutral-positioned wrist splint. Each person will go through three treatment periods in random order: wearing the splint only at night for six weeks, wearing the splint both day and night for six weeks, and a six-week period with no treatment. These periods are separated by three-week breaks, resulting in a total treatment sequence of 24 weeks. Participants will also receive instructions for self-administered stretching exercises and are asked to avoid other medical treatments for this condition during the study. During the trial, participants will complete electronic self-report questionnaires to measure their symptoms, focusing on changes in a six-item symptom scale over six weeks. The study will follow participants for up to one year after starting. Monitoring includes assessing symptom changes after each treatment period, adherence to exercises, and avoiding other therapies to understand the splinting effects.

Acute bronchiolitis is a common reason for hospitalization in infants under one year old, mainly caused by the respiratory syncytial virus (RS-virus). This research compares two ways to stop high flow nasal cannula treatment, which helps infants breathe better. The study aims to find out if stopping the treatment immediately shortens hospital stays and if this approach is safe, compared to gradually reducing the flow rate over time. The study involves two approaches: one group stops high flow nasal cannula therapy at once, while the other group has the flow rate slowly decreased. The high flow nasal cannula is usually set at a flow rate of up to 2 liters per kilogram per minute. The trial examines the use of these two methods in infants with acute bronchiolitis who have been on high flow treatment for at least 12 hours with good oxygen levels. Participants will be monitored for their hospital stay duration after randomization for one week. They will be assessed based on oxygen saturation levels and suitability to stop high flow therapy as determined by their doctors. The study measures how long infants remain hospitalized after stopping treatment immediately or through gradual weaning, focusing on safety and effectiveness of both strategies.