Vantaa

Researchers are evaluating the safety, tolerability, and effectiveness of Pumitamig alone or combined with Ipilimumab or Cabozantinib in adults with advanced Renal Cell Carcinoma (RCC). This phase 1/2 study includes participants with locally advanced or metastatic RCC, including clear cell and non-clear cell types, to better understand treatment options for this condition. The trial aims to assess both side effects and tumor response over an extended period. Participants receive specified doses of Pumitamig alone or in combination with Ipilimumab or Cabozantinib on scheduled days during the study. Nivolumab is also involved as part of the treatment regimen. The study is open-label, randomized, and multi-center, allowing comparison of these treatment approaches over time. The dosing schedules and combinations are carefully monitored throughout the trial. During the study, participants undergo evaluations for adverse events, including serious side effects, dose-limiting toxicities, and events leading to discontinuation or death, monitored up to about two years after treatment ends. Researchers also measure tumor responses using established criteria (RECIST v1.1). Safety and treatment effects are tracked closely to provide comprehensive data on these therapies for advanced RCC.

The ageing population is growing worldwide, and maintaining good oral health in elderly people is increasingly important. Poor dental conditions are common among older adults, with many facing challenges in oral hygiene, especially those in care homes. This study evaluates the use of antibacterial photodynamic therapy (aPDT) combined with antibacterial blue light (aBL) using the Lumoral device as an additional treatment to standard oral care in elderly individuals living at home or in care homes to improve oral hygiene, reduce inflammation, and address dry mouth. Participants will use the Lumoral device at home, which combines a special light-activated mouthwash and antibacterial blue light to reduce plaque and harmful bacteria while supporting saliva production. This device is compared to standard oral hygiene practices, which include professional dental cleaning and self-care methods taught by oral healthcare professionals. The study integrates regular dental appointments with enhanced self-care using the Lumoral device as an adjunctive therapy. During the study, participants' oral health will be monitored through various assessments, including measuring bleeding on probing after 9 months. Researchers will evaluate oral hygiene, inflammation, and dryness of the mouth while tracking safety and adherence to treatments. The trial includes elderly people with at least 10 teeth who can follow the study instructions, and it aims to provide evidence on the effectiveness and safety of the Lumoral device in supporting oral health in this population.

This research aims to evaluate orthodontic screening practices within a publicly funded healthcare setting. The study focuses on how consistently malocclusion, a misalignment of teeth, is evaluated to determine the need for orthodontic treatment. It compares the objective assessment of treatment need with the patient's own subjective perception of that need. Participants will complete a malocclusion impact questionnaire as part of the evaluation process. The study takes place in a public health clinic where the objective and subjective treatment needs are assessed to understand screening repeatability and patient compliance. During the study, participants will be asked to complete questionnaires and undergo evaluations to measure their orthodontic treatment needs. Researchers will monitor the consistency of assessments and compare them with patient-reported treatment needs. The primary outcome measured is the treatment need at the start of the study. The study includes children aged 6 to 16 years and will consider language skills for questionnaire comprehension.

This research aims to understand how anterior open bite malocclusion impacts a person's daily life, evaluate the effectiveness of its orthodontic treatment, and assess the care burden caused by the treatment. The study focuses on the stability of orthodontic correction for this condition and its outcomes over time. Participants with a clinical diagnosis of anterior open bite malocclusion, whether current or past, are included. The study involves orthodontic treatment aimed at correcting the open bite, with outcomes monitored to observe treatment stability. Throughout the study, researchers measure the overbite as the primary outcome over an average period of one year. They assess how the treatment affects participants and monitor the stability of the orthodontic correction. This approach helps understand the long-term effects and care demands associated with treating anterior open bite malocclusion.