Cabestany

Researchers are studying prostate cancer patients undergoing radical prostatectomy to compare three surgical methods robot-assisted laparoscopy, conventional laparoscopy, and laparotomy. The study aims to evaluate the impact of these techniques on urinary and erectile functions, as well as their cost-effectiveness and long-term outcomes. This large, multicenter prospective observational study responds to previous concerns about the lack of high-quality evidence for robot-assisted surgery in prostate cancer treatment. Participants will undergo one of the three prostatectomy procedures robot-assisted laparoscopy, conventional laparoscopy, or laparotomy. Urinary and erectile functions will be assessed before and after surgery using standardized scores like the EPIC 50 and the International Index of Erectile Function IIEF-5. Outcomes including urinary incontinence, erectile dysfunction, and prostate-specific antigen PSA levels will be followed for up to five years. Cost-effectiveness will be evaluated at 12 months using the EQ5d-5L score. Throughout the study, participants will be evaluated at multiple time points, including 45 days and up to five years after surgery, to monitor urinary and erectile functions and other prostatectomy-related effects. Assessments involve questionnaires and clinical measurements. This comprehensive follow-up is designed to help determine the benefits and risks of each surgical approach, supporting informed decisions for patients and healthcare authorities. The study excludes patients without French health insurance or those unable to consent, focusing on adult males scheduled for prostatectomy.

Kidney cancer accounts for 2 to 3% of solid cancers in adults, with over 431,000 cases diagnosed worldwide each year. In France alone, around 13,500 patients undergo total or partial nephrectomy annually. Advances in minimally invasive surgery and enhanced recovery after surgery RAAC programs have shortened hospital stays, but these changes can disrupt patient care quality and follow-up. This research evaluates the use of the UroConnect remote monitoring device to improve patient support and nursing coordination in the perioperative care pathway for kidney tumor surgery. The study compares two groups one receiving standard care without digital follow-up tools, and another using the UroConnect device. UroConnect offers a patient interface for self-questionnaires and educational materials, plus a caregiver interface to help nurses coordinate perioperative care more efficiently. The purpose is to formalize a nurse coordinator role tailored for oncological surgery and to implement tools supporting this role across several French centers. Participants will be monitored for 30 days after surgery, with assessments including unscheduled care use, patient anxiety, satisfaction, reasons for seeking care, and hospital stay length. Longer-term evaluations at 24 months will review device usage, nursing coordination activities, cost analyses, and qualitative feedback. The study aims to better understand how digital coordination affects patients, caregivers, and the healthcare system, with total participation spanning at least two years.

Fever is a common reason for children aged 3 months to 15 years to visit healthcare providers. It can be hard to tell if the fever is caused by a viral or bacterial infection just by examining the child, which sometimes requires additional tests like measuring C-reactive protein CRP. This study looks at using a capillary medical device to measure CRP directly in primary care to help reduce unnecessary referrals to emergency rooms and labs, improving care for febrile children and easing healthcare system burdens. The study compares two groups one using capillary CRP measurement with the ACTIM-CRP device and a control group without this intervention. Children are randomly assigned to these groups during their primary care visit when they have a fever that meets specific duration and severity conditions. The study runs from September 2025 to June 2027 and focuses on referral rates and other outcomes related to care pathways for febrile children. Participants will be involved in the study during their initial consultation and followed up for up to seven days to monitor referrals, antibiotic prescriptions, satisfaction of both general practitioners and parents, fever duration, and cost impacts. Data on complementary tests and healthcare usage will also be collected to understand the effects of using capillary CRP testing in primary care. The study aims to improve the efficiency and quality of care for children with fever.

This clinical trial focuses on men with prostate cancer who are candidates for radical prostatectomy. It aims to compare outpatient versus inpatient robot-assisted radical prostatectomy to determine if managing the procedure as an outpatient leads to similar rates of early post-operative complications. The study evaluates early recovery outcomes and overall patient experience after surgery. Participants will undergo robot-assisted radical prostatectomy either as outpatients or inpatients. The trial compares these two approaches by monitoring early complications from the day of surgery up to eight days afterward. Additional outcomes evaluated include surgery duration, blood loss, recovery of urinary and erectile function, stress and anxiety levels around surgery, patient satisfaction, and longer-term follow-up for up to five years. During the study, participants will visit the clinic at 45 days, 6 months, and annually up to 5 years for check-ups and tests. They will complete surveys on urinary and erectile function, stress, anxiety, satisfaction, and quality of life for six months. Participants are also asked to keep diaries recording treatments and care procedures. Researchers will track hospital readmissions, complications, and economic and social costs related to patient care throughout the follow-up period.

Researchers are investigating kidney cancer through the UroCCR network, a national registry and research platform in France that collects detailed real-world data on patient care and disease progression. Established in 2011, this extensive database includes over 21,000 cases from 58 centers and links clinical information with annotated biological samples and national health data. The platform supports multiple types of research, including translational studies, clinical evaluations, and social science investigations, aiming to improve understanding and management of renal cell carcinoma. The study involves adult patients diagnosed with kidney cancer and documents their treatments, including procedures such as radical or partial nephrectomy as determined by the surgeon. Data collected encompasses clinical parameters, imaging, patient-reported outcomes, and socioeconomic factors. The registry supports prospective research projects and ancillary studies, with a focus on real-world practice following national guidelines. It also integrates digital tools for monitoring and prediction, enhancing personalized treatment strategies. Participants contribute data continuously from enrollment through long-term follow-up, which may last until death or withdrawal. The study collects comprehensive clinical, biological, imaging, and patient-reported information, along with biological samples like plasma, urine, and tumor tissue. Researchers measure outcomes related to research project promotion, biological sample collection, epidemiology, treatment monitoring, quality of life, biomarker research, and clinical practice evaluation. This ongoing data collection supports knowledge advancement and improved kidney cancer care over many years.