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This research focuses on adolescents with very large body sizes, defined as heights greater than +3 standard deviations on updated French growth charts. Most cases are constitutional, meaning related to family height, and are not due to treatable medical conditions. The study aims to evaluate a surgical technique called tibial and femoral epiphysiodesis, which has been used in Northern Europe to limit growth by targeting growth plates near the knees. This approach is being considered as an alternative to hormonal treatments currently used in France, which often cause many side effects. The surgical procedure involves sterilizing the growth cartilage in the distal femur and proximal tibia under general anesthesia using X-ray guidance to ensure complete treatment of the growth zones. The operation lasts about one and a half hours and results in small scars around the knees, with post-operative care including dressings and splints to reduce pain and limit movement. This technique is being offered to families who request treatment to limit excessive height growth. Participants will undergo regular monitoring including measurements of final size, sitting height, and evaluations of any surgery or orthopedic adverse events within one month after surgery. Patient and parent satisfaction will be assessed over five years. The study involves careful assessment of growth parameters, radiological evaluation of growth plate persistence, and psychological evaluation to ensure suitability for treatment. The total follow-up includes long-term observation to assess treatment safety and effectiveness.

Age: 8Years +All GendersPhase Not Applicable
3 locations
Lieusaint Clinical Trials | DecenTrialz