Lisle Sur Tarn

Endometrioma is a condition affecting women of childbearing age, with a prevalence between 23% and 55%. It can cause pelvic pain, reduced fertility, and decreased ovarian reserve. There is currently no clear recommendation for treating large endometriomas, and limited information exists on the best approach to reduce recurrences while preserving fertility and ovarian function. This study aims to assess whether cyst drainage combined with GnRH agonist therapy can lower the rate of endometrioma recurrence, protect ovarian reserve, and impact anti-Mullerian hormone levels. The study involves women aged 18 to 40 with large endometriomas measuring 6 cm or more, diagnosed by MRI or pelvic ultrasound. The treatment being evaluated includes simple laparoscopic drainage of the cyst followed by hormonal therapy using GnRH agonists such as Enantone 3.75 mg or Decapeptyl 3 mg. This approach is practiced at Lille University Hospital to reduce the risks associated with cystectomy. Participants will be monitored for recurrence of cysts 3 cm or larger using MRI or pelvic ultrasound at 3 months after treatment. Researchers will evaluate the effects on ovarian reserve and hormone levels. The study excludes women who are pregnant, have contraindications to laparoscopy, general anesthesia, or GnRH agonists, or who decline participation. The total duration and other follow-up details are structured to assess treatment safety and effectiveness comprehensively.