Pont Saint Martin

This research aims to evaluate the real-life effectiveness, safety, usage, tolerance, and satisfaction of four CE-marked isotonic and hypertonic seawater-based nasal sprays. It focuses on infants, children, adults, and pregnant or breastfeeding women who suffer from acute and chronic sinonasal conditions such as upper respiratory tract infections, COVID-19, bronchiolitis, allergic rhinitis, chronic rhinosinusitis, and post-surgery recovery. The study seeks to answer key questions on how well these nasal sprays work and how safe and satisfactory they are in everyday use. Participants will use one of four nasal sprays designed for different age groups and indications. The sprays are applied by spraying 1 to 3 seconds into each nostril multiple times daily, depending on the product and condition. Treatment for nasal symptoms ranges from 2 to 6 times a day, while hygiene and prevention uses are less frequent. The nasal sprays are used according to their intended purpose and population, including special instructions for babies, children, and adults. During the study, participants or their parents/caregivers will perform nasal washes following healthcare provider advice and complete online questionnaires about their symptoms and experience. Researchers will monitor nasal symptom improvement over 5 days for acute conditions and up to 14 days for chronic conditions. The study includes assessments of nasal symptom intensity, nasal breathing impairment, safety, and user satisfaction. Participants are expected to comply with study requirements for up to 3 months and have daily internet access for questionnaire completion.

Researchers are evaluating the effectiveness of a hypnotherapy method called E2R in managing chronic insomnia in primary care. Chronic insomnia is commonly treated with hypnotic drugs in France, though these have notable side effects. Cognitive-behavioral therapy is recommended as a first-line non-drug treatment but is not widely used due to limited availability and time demands. The study aims to compare E2R hypnotherapy to standard care without hypnosis in patients with chronic insomnia. Patients will be randomly assigned to one of two groups: the E2R hypnosis group or the standard care control group. Those in the hypnosis group will receive four 30-minute hypnotherapy sessions over six weeks with a hypnotherapist located within 30 minutes of their home. The control group will receive the usual care by their general practitioner, which may include psychotherapy or medication but will exclude hypnosis. Both groups will have follow-up visits at three and six months after randomization. During the study, patients will complete questionnaires such as the Insomnia Severity Index and Pittsburgh Sleep Quality Index. Researchers will track use of psychotropic medications, any non-drug therapies, practice of self-hypnosis, events affecting sleep, and any adverse neuropsychiatric events. The main outcome measured is the severity of insomnia at six months. Safety and treatment effects will be assessed through these follow-ups, with the total study duration being six months.