Saint Junien

Sepsis and its severe form, septic shock, are serious health concerns characterized by organ failure and acute circulatory problems like low blood volume, blood vessel dilation, and heart dysfunction. Researchers are evaluating whether measuring microcirculation parameters such as the peripheral perfusion index and skin marbling by nurses can improve early treatment decisions and patient outcomes. This study focuses on the early detection of tissue blood flow problems that may not be obvious through standard measurements and aims to assess if early vascular filling based on these measures can reduce deterioration and mortality. Participants will be monitored using classic hemodynamic parameters plus additional measurements of peripheral perfusion index and marbling score. If the peripheral perfusion index is 3 seconds or more or marbling is present at a score of 1 or higher, nurses will initiate a vascular filling test by administering 500 cc of fluid over 30 minutes after confirmation by a senior doctor. All patients will continue to receive standard care treatments. This intervention period is closely linked to emergency department admission. Throughout the study, patients will be followed for 7 days to track clinical outcomes including deterioration within 24 hours after inclusion, organ function changes, mortality, lung fluid overload, and care setting decisions such as discharge or intensive care admission. The study also compares nurse and physician assessments of microcirculation. This detailed monitoring includes timing of treatment bundles and safety checks to evaluate how early microcirculation measurement impacts sepsis management and patient prognosis.

This research investigates how common sexual dysfunction is among women after rectal cancer surgery and examines the effects of a sexologists intervention. It focuses on women with stage I-III rectal adenocarcinoma or rectosigmoid junction cancer and aims to improve understanding of sexual health issues in this group, which has been less studied compared to men. The study compares two groups one receiving standard care without sexologist support and another receiving consultations from a sexologist before and after surgery. The sexologist evaluates sexual dysfunction and provides help to improve sexual quality of life if problems are identified. Both groups undergo surgical management with or without preceding radio-chemotherapy. Participants will be assessed before treatment and followed up at 6 and 12 months after surgery. Researchers will measure sexual function using the Female Sexual Function Index FSFI and track changes in sexual satisfaction over time. The study is non-randomized and involves no masking. The total participation duration covers assessments at one month before treatment and at 6 and 12 months post-surgery.

This research aims to collect detailed information about hypoparathyroidism in France, a condition with few epidemiological studies worldwide and none specific to France. The study focuses on understanding the frequency of this condition, the medications used, and the complications it may cause, such as low calcium symptoms, calcifications in the brain and tissues, kidney stones, and kidney problems. Participants will not receive any treatment as part of this study since it is observational. The study gathers data from patients diagnosed with chronic hypoparathyroidism living in France to assess their medical history, current treatments, and any complications related to their condition. There is no intervention or drug administration involved. During the study, researchers will review participants biological data including calcium, urine calcium, parathormone, creatinine, phosphate, and magnesium levels at diagnosis and during treatment. They will also collect information about patient management and complications. This data collection will continue for about two years, helping to understand the conditions progression and treatment outcomes in the French population.