Saint Maurice

This research aims to understand neuropathic pain in children and adolescents who had limb amputations during childhood. It focuses on two types of neuropathic pain phantom limb pain and residual limb pain. The study also looks at quality of life and functional independence in these young patients, exploring links between pain, autonomy, quality of life, and age when the amputation occurred. This observational study uses both past medical records and questionnaires to gather information without changing patient care. Participants are children and teens aged 5 to 18 years who had limb amputations before age 15 for girls and 16 for boys. The study collects data from medical records and standardized questionnaires during routine follow-up visits at a specialized pediatric limb anomaly center. There is no treatment or intervention data collection happens at a single time point to assess neuropathic pain and its effects. During the study, participants provide information through questionnaires about neuropathic pain, quality of life, and functional abilities. Researchers also review medical records for relevant history. The main measure is the presence of neuropathic pain after amputation. Other outcomes include types of pain, health-related quality of life, locomotor and upper limb function, and correlations between pain scores and age at amputation. Participation involves only one visit during routine care, with no extra procedures or treatments.

Researchers are investigating infrapatellar fat pad IFP impingement syndrome, a common cause of front knee pain, to improve its diagnosis. This observational study aims to assess the accuracy of a set of standardized clinical tests for diagnosing IFP impingement by comparing them to MRI results, which are currently the gold standard. The study also seeks to identify clinical and subjective features linked to IFP involvement confirmed by imaging. Participants aged 18 to 70 years with anterior knee pain of at least moderate intensity will complete an online questionnaire about their symptoms, pain patterns, and functional impact using validated scales. They will undergo a standardized clinical exam including skin temperature measurement, knee swelling assessment, passive knee motion testing, and five randomized clinical provocation tests targeting the infrapatellar fat pad. Each participant will also have a knee MRI within two weeks of the clinical exam, interpreted independently and blindly. Participant involvement includes a single session during a routine consultation where clinical tests and questionnaires are completed, followed by MRI imaging within 15 days. Data collected will be anonymized and analyzed to determine the diagnostic accuracy of the clinical tests compared to MRI findings. Researchers will also evaluate functional outcomes, pain intensity, and clinical characteristics associated with IFP impingement. The study plans to recruit 50 participants over six months, with results expected to improve routine diagnosis of anterior knee pain related to IFP.

This trial focuses on babies with obstetrical brachial plexus palsy OBPP, a condition causing shoulder muscle deformity that leads to reduced shoulder movement, pain, and social participation difficulties. Researchers are studying whether early injections of botulinum toxin type A BTI into the shoulder muscles at 12 months of age can prevent worsening shoulder deformities compared to a simulated sham procedure. The study is designed as a randomized, double-blind clinical trial sponsored by University Hospital, Brest. Participants are randomly assigned to receive either the botulinum toxin injection or a sham injection at 12 months old. The botulinum toxin dose is 8 UIkg, divided among specific shoulder muscles. The sham group undergoes a simulated injection mimicking the procedure without the active drug. The study measures effects at 11 months before injection and at 18 months six months after injection, with long-term follow-up until 10 years old to assess surgical intervention frequency. Throughout the study, babies will undergo MRI scans to measure shoulder joint positioning and assess muscle condition. Researchers will also evaluate shoulder movement range, upper limb function, and treatment tolerance. The primary outcome is the change in shoulder joint position between 11 and 18 months. Secondary outcomes include muscle condition, joint deformity, and the need for surgery over time. Participation involves clinical assessments and imaging at specific ages, with safety and effectiveness monitored closely.

Schizophrenia, affecting about 0.7% of the population, often leads to poor insight and medication compliance, resulting in relapses and a reduced quality of life. Researchers are evaluating an individual early psychoeducation program called PEPITS for inpatients with schizophrenia or related disorders. The study aims to see if PEPITS can reduce relapses, improve medication adherence and insight, and enhance quality of life. The PEPITS program is delivered by nurses during the initial hospitalization phase and consists of three parts an introduction session, sessions focused on understanding the illness and care, and sessions on recovery and building coping skills. Participants are randomly assigned to either the PEPITS program or to usual psychiatric care without PEPITS. Participants will be monitored from the start of the study until one year after randomization to assess changes in insight, quality of life, and medication compliance. Additional evaluations include quality of life and psychological well-being at work, job satisfaction, self-efficacy, and work commitment over six months. The study involves regular assessments to track these outcomes and better understand the programs impact.

Unilateral Spatial Neglect USN is a common condition after stroke, causing difficulties in noticing and responding to things on one side of space opposite a brain injury. This study evaluates the effectiveness of an immersive virtual reality rehabilitation program that uses musical practice to help patients with USN. It also looks at how this program might improve daily life and how mood and motivation influence its benefits. Participants will receive either conventional rehabilitation alone or a combination of conventional rehabilitation and immersive virtual reality rehabilitation using the Piano Vision application, which offers free or guided musical practice. Each patient will undergo two rehabilitation periods of two weeks each, with the order of treatments randomized. The study compares these two approaches to see which provides better outcomes. During the study, patients will have assessments before and after rehabilitation, including tests like the Bells Test, Mesulam cancellation, bisection tasks, and ecological evaluations of daily activities. Virtual reality-based tasks and musical skill tests are also included. Mood and motivation will be measured at four weeks. The total follow-up period includes evaluations up to eight weeks, allowing researchers to monitor changes and effects over time.

People with mental disorders tend to smoke more than the general population, which contributes to a significant reduction in their life expectancy by 10 to 20 years, mainly due to heart and lung diseases such as bronchial cancers. Despite this, smoking cessation efforts tailored for psychiatric patients are limited, as smoking is often overlooked or accepted in mental health care settings. This study aims to assess a smoking cessation program called Tabapsy designed with input from mental health users, professionals, and general practitioners, focusing on adult patients receiving outpatient psychiatric care. The Tabapsy intervention includes a campaign promoting smoking cessation within psychiatric medical psychological centers CMPs and a series of supportive activities. These activities involve an initial information meeting to boost motivation, an assessment workshop to evaluate nicotine dependence and create personalized quitting plans, five thematic workshops covering nicotine replacement, emotional management, weight control, physical activity, and manual tasks, and peer support groups for shared experiences. A dedicated facilitator will lead these sessions, supported by an online resource website. The study compares the intervention against usual care in a national cluster-randomized trial involving psychiatric sectors. Participants who smoke regularly and consent will complete questionnaires via a web app at the start, 3 months, and 6 months, with additional surveys for those in the intervention group. The questionnaires cover smoking habits, dependence, motivation, cessation aid use, mental and physical well-being, and knowledge about tobacco. The main outcome is smoking cessation lasting at least 7 days at 3 months. Secondary outcomes include cost-effectiveness, implementation, quit attempts, and satisfaction. A total of 6,250 participants will be enrolled over 12 months across 22 sectors.

This research aims to understand the medical, social, and organizational factors that influence returning to work after osteoarticular trauma, especially limb fractures. These injuries often affect working-age adults and can lead to long absences from work with significant social and economic consequences. The study focuses on how various factors like injury severity, pain, job type, workplace support, and disability recognition affect the process of getting back to work within 12 months after the injury. Participants are adults who experienced osteoarticular trauma and were employed before the injury. The study collects data from their medical records and self-reported questionnaires without changing their usual care. It looks at when and how patients return to work, any workplace accommodations made, and when discussions about returning to work happen during hospital stays. During the study, participants provide information through questionnaires, and researchers review their medical records to assess return-to-work rates and timing, workplace adjustments, and disability recognition. The main outcome is the rate of returning to work within 12 months, along with factors that influence this process. The study also examines the timing of return-to-work discussions during hospitalization to identify gaps in early planning for professional reintegration.