Saint Priest

Researchers are conducting a phase 3, multicenter, open-label, randomized study to evaluate new treatments for adults with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplantation (ASCT). The study aims to compare the effectiveness and safety of a combination of elranatamab and lenalidomide as a replacement for standard chemotherapy during the consolidation phase, and to assess elranatamab alone versus standard care during maintenance therapy. Participants will first receive standard induction therapy with four cycles of a drug combination called D-VRd. After this, they will be randomly assigned to either receive standard consolidation therapy involving high-dose chemotherapy and ASCT followed by D-VRd consolidation (Arm A), or elranatamab combined with lenalidomide for consolidation (Arm B). Upon completing consolidation, patients will be re-randomized to receive maintenance treatment with either lenalidomide alone (Arm C) or elranatamab alone (Arm D). During the study, participants will be monitored for treatment effects including minimal residual disease negativity at the end of consolidation, progression-free survival, and overall survival. The study involves various assessments including clinical evaluations, laboratory tests, and monitoring for disease progression or side effects. The entire treatment and follow-up period may last up to several years, allowing researchers to evaluate long-term outcomes and safety.

Human papillomaviruses (HPV) are common contagious viruses that infect about 70% of men and women at some point in their lives. Vaccination has been recommended since 2007 for girls and since 2021 for all young people aged 11 to 14, with catch-up vaccination possible up to age 26. Despite these recommendations, vaccination rates remain low in France, especially in the Auvergne Rhône Alpes region, where only 47.5% of girls and 12.3% of boys are vaccinated. This study aims to evaluate the effect of a primary prevention program delivered in middle and high schools on increasing the HPV vaccination rate among adolescents aged 11 to 17 at 6 months. The intervention consists of a 1.5-hour educational presentation for 9th grade middle school and 12th grade high school classes. During this session, students will learn key information about HPV, including what it is, how it spreads, who it affects, its possible consequences, and how to protect themselves. The presentation includes a discussion and an interactive game identifying cancer locations linked to HPV infection, supported by materials like posters and a silhouette game. Participants will be monitored for HPV vaccination uptake six months after the intervention. The study involves middle and high school students and their teachers from public schools in the Auvergne Rhône Alpes region. Researchers will assess vaccination status and collect data to determine the intervention's impact. Participation requires reading and understanding French and having parental consent for minors. The study's overall goal is to help increase HPV vaccination coverage toward national targets.

Researchers are investigating how to improve preventive health practices related to nutrition, physical activity, and sedentary behavior in adults who visit primary care doctors in France. The study focuses on behavior change, which is a major factor in chronic health conditions. It aims to develop and test a training program for general practitioners (GPs) to better support patients in making healthier lifestyle choices. This approach builds on the successful "Healthy Conversation Skills" program used in England and adapted to French culture and healthcare systems. The study compares two groups of GPs: one that receives specialized training to deliver brief, opportunistic support on diet, physical activity, and sedentary time during routine consultations, and another that does not receive this training. The training includes online courses, simulation workshops, personalized coaching, and patient support materials. It is designed collaboratively with GPs and patients to fit the French primary care context. Participants will be adults registered with participating GP practices who are at early stages of changing their exercise or diet behaviors. Researchers will assess patients' motivation to change their diet and physical activity using specific scales two weeks after their consultation. The study will monitor the effectiveness of the GP training in encouraging healthier behaviors and will track outcomes related to readiness for change. The total duration and further follow-up details are not specified.