Vesoul

Colorectal cancer is a common cancer with increasing cases each year. Early detection is very important, and in France, people aged 50 to 74 are screened using a fecal immunological test to find hidden blood in the stool. If this test is positive, a colonoscopy is performed to check for polyps or cancer. Due to delays caused by the COVID-19 pandemic, researchers are exploring a new blood test to quickly identify patients with colorectal cancer and help guide timely treatment. The study involves two groups of patients: Cohort A includes those with suspected colorectal cancer after a positive stool test or visible bleeding, and Cohort B includes patients diagnosed with adenocarcinoma confirmed by pathology before surgery. Blood samples will be collected before colonoscopy or surgery and again one month after surgery to analyze various blood components. Tumor tissue will also be collected during surgery for study purposes. Stool samples are collected before and after surgery in Cohort B. Participants will undergo these sample collections and evaluations as part of the study. Researchers will measure how accurately the blood test detects colorectal cancer and its correlation with disease stage. The main outcomes are the sensitivity and specificity of the blood test one month after surgery, about six months after joining the study. The study is designed to improve patient care during challenges like epidemics by providing a new tool for early cancer detection and treatment planning.