Villenave D Ornon

Researchers are evaluating a new way to set mechanical ventilators for patients with acute respiratory distress syndrome (ARDS) to reduce death rates within 60 days. This trial includes adults with moderate to severe ARDS, whether caused by COVID-19 or other reasons, and compares a ventilation method based on lung mechanics to standard care. ARDS affects lung function severely, making ventilation challenging, and this study aims to find the best bedside ventilation approach to avoid further lung injury. The study has two groups: one where ventilator settings are personalized using bedside respiratory mechanics measurements like recruitability and airway closure, adjusting pressures to protect the lungs; and a control group receiving standard ventilation based on oxygen levels and standard protocols. Ventilation settings are carefully adjusted during the study, including volume control at specific levels and monitoring spontaneous breathing efforts. The design includes two sub-studies with shared procedures for both COVID-19 and non-COVID-19 ARDS patients. Participants will be monitored for 60 days to measure overall mortality. During the study, patients receive detailed assessments including breathing mechanics, oxygen levels, and ventilator parameters. Researchers track lung function and adjust treatments accordingly while ensuring safety limits. The trial collects data on how well the ventilation strategies protect the lungs and support recovery over this period.