Voiron

Researchers are conducting a prospective, multicenter cohort study to follow children with idiopathic nephrotic syndrome INS, a rare kidney disease. The study aims to collect data on pediatric patients treated by pediatric nephrologists in France and its overseas territories to better understand the diseases characteristics and support future clinical trials. The study involves regularly recording medical, biological, psychological, and social data through routine clinical follow-ups, hospitalizations, and consultations. Additionally, annual telephone interviews will be conducted for patients in remission. Quality of life, treatment adherence, and treatment impact questionnaires will also be collected. A biobank is established to collect blood, urine, hair, and nail samples at the disease onset before immunosuppressive treatment begins. Participants will be followed from disease onset until age 18 or transfer to adult nephrology care. Data is collected via a secure website, medically validated and entered by clinical research staff. The main outcome is the number of cases included and their characteristics over two years. Participation involves routine care visits, interviews, and questionnaires, with continued monitoring planned through the study period ending in 2048.

This research aims to understand whether an early follow-up visit with a primary care doctor within one month after hospitalization in a geriatric medicine department can reduce the risk of being readmitted to the hospital within three months. Hospital readmissions are a significant public health concern, especially in elderly patients who often have multiple health issues and are more vulnerable to complications during and after hospital stays. The study focuses on elderly patients aged 75 and older, recognizing the high medical, social, and financial impacts of frequent hospitalizations in this population. The study is observational, meaning no treatments or interventions are assigned. Participants will be grouped based on whether they have an early consultation with their primary care physician within one month after leaving the hospital or not. Researchers will collect information through short telephone calls at 1 and 3 months after discharge to ask about the patients return home and hospital readmission status. This approach helps observe the natural effects of early follow-up care without altering usual medical practices. Participants will be monitored through brief phone interviews lasting 5 to 10 minutes at one and three months after hospital discharge. Researchers will assess the impact of early primary care follow-up on rehospitalization rates, length of hospital stays, mortality at 1 and 3 months, and healthcare costs. The study does not involve direct risks or treatments but aims to provide evidence that could support better post-hospital care strategies for elderly patients. Total participation lasts about three months after hospital discharge.

Chronic pain affects a large portion of adults and elderly people worldwide, leading to significant personal and societal challenges such as reduced work ability and high economic costs. Current treatments often have limited effectiveness and notable side effects. This research aims to better understand chronic pain by creating an e-cohort using a smartphone app and web platform to support personalized follow-up and characterization of patients in pain clinics. Participants will use the eDOL tool, which includes a mobile application for patients and a web platform for healthcare providers. This tool collects various data through repeated questionnaires, weekly assessments, educational modules, and a chat bot. The study involves 20 pain clinics and plans to enroll at least 5000 patients, following them for 24 months to gather comprehensive real-life information on pain, comorbidities, treatment, and psycho-emotional impacts. During the study, participants will regularly provide data through the eDOL app, while researchers will link this information with French health insurance records to analyze healthcare usage and comorbid conditions. The main goal is to characterize chronic pain patients in multiple dimensions over five years. Data analysis will include descriptive and longitudinal methods to understand chronic pain better and improve care approaches.

Researchers are studying the potential benefits of outpatient care for patients with acute uncomplicated appendicitis treated by laparoscopic appendectomy. This research aims to compare outpatient care with conventional hospital care to see if outpatient care is not worse in terms of overall morbidity and mortality within 30 days after surgery. The study is motivated by the need to optimize care pathways, reduce hospital stays, improve patient satisfaction, and lower healthcare costs, especially important during the COVID-19 pandemic. The trial compares two treatment groups one receiving ambulatory appendectomy where surgery is done in an outpatient surgery unit and patients are discharged the same day, and the other receiving conventional appendectomy where surgery occurs in the digestive surgery department and patients stay overnight for observation before discharge. The study evaluates outcomes up to 30 days after surgery, including hospital stay length, rehospitalization rates, complications, re-interventions, patient satisfaction, quality of life, and economic impacts. Participants will undergo assessments before and after surgery, with monitoring of clinical outcomes, patient satisfaction, and quality of life at 7 and 30 days post-operation. Researchers will also track safety, the rate of conversion from outpatient to conventional care, and costs associated with each care pathway. The total study participation includes follow-up for 30 days after surgery to assess the main and secondary outcomes.