Voiron

Researchers are creating a national, prospective cohort to study children with idiopathic nephrotic syndrome (INS), a rare kidney disease. The goal is to collect detailed data on patients treated in pediatric nephrology centers across France, Reunion Island, Mayotte, and eventually other French overseas territories. This structured follow-up aims to better understand the disease's characteristics and provide a foundation for future clinical trials. The study involves enrolling pediatric patients diagnosed with INS and systematically collecting clinical, biological, psychological, and social data. Biological samples such as blood, urine, hair, and nails will be gathered at disease onset before immunosuppressive treatment begins. Data will be recorded through medical records from hospital visits and consultations, supplemented by annual telephone interviews for patients without active disease. Quality of life, treatment adherence, and aesthetic impact questionnaires will also be collected and integrated into a secure database. Participants will be followed over at least two years, with data collected regularly by clinical research staff. This includes medical validation of clinical information, annual telephone follow-ups, and questionnaire assessments. The study's primary outcome is the number and characteristics of included cases over two years. This ongoing monitoring will support future nested studies and improve understanding of pediatric INS outcomes and management.

The trial investigates the impact of early consultation by primary care physicians on elderly patients who have been hospitalized in geriatric medicine. Hospital readmission is a major public health concern due to medical costs and risks, especially for fragile elderly populations who often have multiple health issues. The study aims to see whether a follow-up visit within one month after discharge can reduce the risk of rehospitalization within three months. Participants are elderly patients aged 75 or older who have been hospitalized in a geriatric department and discharged home. The study focuses on whether these patients receive an early consultation by their primary care physician within one month after hospital discharge. The research does not involve experimental treatments but observes the association between early physician consultation and rehospitalization rates. During the study, researchers will collect data on rehospitalization occurrences at one and three months after hospital discharge. They will monitor patient outcomes through hospital records and physician consultations. The study is observational and does not pose direct risks or benefits to participants. It aims to provide data that could support prioritizing early follow-up care to reduce rehospitalization and associated healthcare costs.

Chronic pain affects a significant portion of adults and elderly individuals worldwide and presents major societal and economic challenges, including reduced work ability and high healthcare costs. Current treatments often have limited success and notable side effects, leading to a need for better therapeutic options and care organization. This research aims to create a French e-cohort to enable personalized monitoring and detailed characterization of chronic pain patients using innovative digital tools. Participants will use the eDOL system, a digital health tool that includes a smartphone app for patients and a web platform for healthcare providers in pain clinics. This system collects a wide range of data through repeatable questionnaires, weekly symptom tracking, therapeutic education, and a conversational agent. The study will enroll a minimum of 5000 patients from 20 pain clinics and follow them for 24 months to gather comprehensive real-life information. Throughout the study, data on pain, related conditions, sleep, activity, emotional factors, demographics, and treatments will be collected and linked to French health insurance records to assess care usage and comorbidities. Researchers will analyze these data over five years to better understand chronic pain and its impacts. Participants will regularly complete assessments via the eDOL app, enabling ongoing monitoring and personalized follow-up in real-world settings.

Researchers are evaluating the safety and quality of outpatient care compared to conventional hospital care for patients with acute uncomplicated appendicitis who undergo laparoscopic appendectomy. The study focuses on whether same-day discharge is as safe and effective as staying overnight in the hospital. This approach aims to improve patient satisfaction, reduce hospital stays, lower healthcare costs, and limit exposure risks during situations like the COVID-19 pandemic. The trial compares two treatments: ambulatory appendectomy, where the surgery is done in an outpatient unit and patients leave the hospital the same day, and conventional appendectomy, where patients stay overnight under observation after surgery in a digestive surgery department. Patients included are those with confirmed uncomplicated appendicitis and meet specific health and monitoring criteria, such as having a relative available for monitoring after discharge and living close to a hospital. Participants will be followed for 30 days after surgery to monitor overall safety and recovery. Researchers will assess complications, health status, and any morbi-mortality events during this period. The study includes careful screening before surgery, ongoing safety monitoring, and uses imaging and laboratory tests to confirm eligibility and health status. The total participation period covers the surgery day and 30 days of postoperative follow-up.