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This research aims to explore the genetic and molecular factors of gout, inflammation, and metabolic diseases in French Polynesia, where gout affects about 15% and hyperuricaemia impacts over 70% of adults. The study focuses on understanding the molecular, physical, and pathological features related to these conditions, especially given the high rates of obesity and diabetes in the population. It also seeks to clarify the genetic contributions and inflammatory responses involved in gout and its links to other cardiometabolic diseases. Participants will be involved in an epidemiological study that includes collecting sociodemographic information, treatment data, clinical examinations, and completion of various health questionnaires related to gout, pain, diet, physical activity, and more. Blood and urine samples will be collected for genetic, biochemical, and other analyses to assess cardiometabolic health. The study builds on a previous French Polynesia study named TOPATA, aiming to expand the cohort and track long-term effects of hyperuricaemia. During the study, participants will undergo physical and biological assessments, clinical examinations, and answer detailed questionnaires. Researchers will monitor genetic variants linked to health traits over 12 months. The study involves fasting for sample collection and may require follow-up visits, especially for those experiencing gout attacks. Data collected will help better understand the disease mechanisms and potentially improve diagnosis and treatment in this high-risk population.