Genetic and Molecular Study of Gout, Inflammation, and Metabolic Diseases in French Polynesia

What this Trial Is About

Researchers are investigating the genetic and molecular factors involved in gout, inflammation, and metabolic diseases in French Polynesia. This study aims to better understand the high rates of gout and hyperuricaemia in the adult population, as well as related conditions like obesity and type 2 diabetes. The goal is to identify genetic contributors and track the long-term effects of hyperuricaemia and associated health risks. Participants are grouped into the general population, gout patients, and a follow-up group from a previous 2021 study called TOPATA. The study involves collecting sociodemographic data, clinical exams, questionnaires, and blood and urine samples for genetic and biochemical analyses. Some gout patients with recent attacks will provide additional samples one week later to monitor acute flare changes. During the study, participants will undergo various assessments including physical exams, laboratory tests, and questionnaires about health, diet, and lifestyle. Researchers will measure genetic associations, correlations between gout and metabolic conditions, disease progression, and cardiovascular events. The study spans several years, with key outcomes assessed at 12 months and up to 4 years, to better understand disease mechanisms and support future therapies.

Landscape of Gout in French Polynesia.