Pirae

Researchers are exploring how liquid biopsy can improve treatment for patients with metastatic cancer in community healthcare settings. This study involves patients with metastatic cancer, either newly diagnosed or recurring after initial treatment, who are eligible for first-line treatments such as chemotherapy, immunotherapy, endocrine therapy, or targeted therapy. Various tumor types are included, such as metastatic prostate cancer resistant to castration and specific types of metastatic breast cancer resistant to endocrine therapy. Participants will have a blood sample taken before starting treatment, which will be analyzed using Next Generation Sequencing to examine a broad panel of genes and microsatellite instability status. The test results will be reviewed by a Molecular Tumor Board involving multiple centers to guide treatment decisions. This approach aims to tailor precision medicine in community hospitals. During the study, patients' blood samples and clinical data will be collected and monitored over a period of 72 months to assess the proportion of patients for whom circulating tumor DNA sequencing is informative. Researchers will track treatment outcomes and safety while gathering detailed information about tumor genetics and responses to therapy. The study requires informed consent and ongoing participation for long-term follow-up.

This research aims to explore the genetic and molecular factors of gout, inflammation, and metabolic diseases in French Polynesia, where gout affects about 15% and hyperuricaemia impacts over 70% of adults. The study focuses on understanding the molecular, physical, and pathological features related to these conditions, especially given the high rates of obesity and diabetes in the population. It also seeks to clarify the genetic contributions and inflammatory responses involved in gout and its links to other cardiometabolic diseases. Participants will be involved in an epidemiological study that includes collecting sociodemographic information, treatment data, clinical examinations, and completion of various health questionnaires related to gout, pain, diet, physical activity, and more. Blood and urine samples will be collected for genetic, biochemical, and other analyses to assess cardiometabolic health. The study builds on a previous French Polynesia study named TOPATA, aiming to expand the cohort and track long-term effects of hyperuricaemia. During the study, participants will undergo physical and biological assessments, clinical examinations, and answer detailed questionnaires. Researchers will monitor genetic variants linked to health traits over 12 months. The study involves fasting for sample collection and may require follow-up visits, especially for those experiencing gout attacks. Data collected will help better understand the disease mechanisms and potentially improve diagnosis and treatment in this high-risk population.

Researchers are evaluating skin reactions related to thoracic implantable catheter chamber dressings in patients newly treated with systemic chemotherapy. This study focuses on the incidence of skin issues such as redness, itching, and dermabrasion caused by semi-permeable film dressings used in oncology, especially given the high frequency of these reactions and their impact on patient comfort. It aims to explore factors influencing skin tolerance, including individual traits, treatment side effects, dressing application methods, duration, and environmental conditions. The study will include a prospective, multicenter cohort of 500 patients, all receiving thoracic implantable catheter chambers as part of their first line of chemotherapy treatment. The investigation involves monitoring skin reactions over an average of 18 months, with data collected from different regions including the French West Indies to assess potential variations related to climate and skin type. Participants will be observed throughout the study period to measure the incidence of skin reactions associated with their implantable chamber dressings. Researchers will gather information on patient characteristics, treatment details, and environmental factors. The study emphasizes careful monitoring and documentation of skin reactions to improve understanding and potentially enhance care practices for patients using these devices.