Bietigheim Bissingen

Researchers are evaluating the effectiveness of a new commercial toothpaste that contains a novel compound aimed at supporting a healthy oral microbiome in people with periodontitis. This study is conducted at multiple centers and involves volunteers who regularly receive professional tooth cleaning every 3 to 6 months as part of their supportive periodontitis therapy. The study aims to compare the dental hygiene maintained by using this new toothpaste versus regular cleaning methods during a 3-month period. During the study, participants will brush their teeth twice daily using the assigned toothpaste and will be asked not to rinse their mouth after spitting out the toothpaste. The study product includes standard ingredients like sodium fluoride and cleaning agents along with the new microbiome-modulating compound. Participants will continue their regular professional tooth cleaning schedule between 2 recall visits, and the treatment effect will be observed over a 12-week period. Participants will be assessed at the start and end of the 3 months for the toothpaste's efficacy, focusing on changes in oral health and microbiome balance. The study monitors safety and effectiveness through clinical evaluations, including microbiological analysis of biofilm and oral health status. The total participation time covers the 12 weeks of treatment and observation.