Kremmen

This research aims to determine the best duration of blood-thinning medication after elective total hip arthroplasty THA to prevent blood clots. The study compares a shorter 10-day course versus the standard 35-day course of anticoagulation after hip replacement surgery. It focuses on patients eligible for early mobilization and evaluates whether the shorter treatment is as effective at preventing dangerous clots within 90 days after surgery. The trial randomly assigns patients to one of two groups one receiving the anticoagulant rivaroxaban from day 3 to day 10 post-surgery followed by placebo until day 35, and the other receiving rivaroxaban continuously for 35 days. Both groups follow a standard enhanced recovery protocol with early mobilization after surgery. This double-blind study includes an initial two-day open-label anticoagulation period before randomization. Participants will have follow-up visits on day 35 and day 90 after surgery to monitor for blood clots, bleeding events, and overall recovery. Researchers will assess outcomes including symptomatic deep vein thrombosis, pulmonary embolism, hospital stay length, joint function, and quality of life. Safety and any adverse events will be closely tracked during these visits to understand the benefits and risks of shorter anticoagulation treatment after hip replacement.

Researchers are evaluating the effects of two different cryotherapy methods on postoperative swelling and pain after primary total knee arthroplasty TKA. The study aims to compare cuff cooling cryotherapy with conventional ice pack treatment to determine potential differences in reducing swelling and pain following knee replacement surgery. This interventional study does not use randomization or masking and is led by Prof. Dr. med. Andreas Halder. Participants will receive one of two treatments after surgery either cryo cuff cooling or conventional ice pack cooling applied postoperatively. The study groups include patients treated with the cryo cuff device and those treated with standard ice packs. The research will observe these treatments over a 4-week period following enrollment and surgery. During the study, participants will be examined before and after surgery according to a set examination and data collection plan. They will document their pain using a numeric rating scale NRS and report feelings of tightness at the 4-week mark. Researchers will measure postoperative swelling and pain from enrollment up to 4 weeks after surgery, along with the demand for painkillers. The total duration of participation includes follow-up for these outcomes over the 4 weeks after surgery.