Schenefeld

This clinical trial evaluates the effectiveness of an antimicrobial mouthrinse in reducing established dental plaque and improving gum health in adults with gingivitis and dental plaque accumulation. The study focuses on measuring improvements in gum health using the Gingival Index and plaque reduction using the Plaque Index over a six-month period. Participants include adults aged 18 to 70 years who have at least 20 natural teeth and meet specific oral health criteria. Participants are randomly assigned to one of two groups the test group using a mouthrinse containing 0.0553% sodium fluoride, amine, and 0.2% zinc lactate dihydrate, or the control group using a mouthrinse with 0.0553% sodium fluoride only. Both groups will brush their teeth twice daily with provided toothpaste and toothbrush, then rinse with 15 ml of the assigned mouthrinse for 30 seconds. This routine continues for six months. Throughout the study, participants visit the clinic every three months after the baseline visit for reassessment. Researchers monitor gum health improvements and plaque levels using standardized indices. The study also includes safety monitoring and requires participants to maintain good general health and adhere to the treatment regimen. The total duration of participation is six months, with regular assessments to evaluate treatment effects.

This research aims to evaluate the self-adhesive properties of three different investigational silicone devices designed as dressings. The study is conducted with healthy volunteers to compare two investigational devices against a reference device, focusing on their ability to stay adhered over time. The investigation is exploratory and single-center, involving non-sterile silicone self-adhesive devices. Participants will have 12 dressings applied to designated areas on their backs to test and compare the dressings staying power. The dressings will be worn for up to 14 days, and the study will assess the dressing and application regimen during this period. The investigation includes the application and monitoring of these devices on intact skin with minimal hairiness. During the study, volunteers will undergo multiple visits and assessments to monitor the dressings and application sites. Researchers will measure the primary outcome of how well the devices stay on from enrollment until 14 days later. Participants must follow specific instructions to avoid contact with water, detergents, and cosmetics on the application sites during the study. The total participation duration lasts approximately two weeks, and adherence to the protocol is closely observed.