Schenefeld

Researchers are evaluating the effectiveness of an antimicrobial mouthrinse in reducing established dental plaque and improving gum health in adults with gingivitis and dental plaque accumulation. This Phase 4 clinical study aims to compare the benefits of a test mouthrinse containing fluoride, amine, and zinc lactate with a control mouthrinse containing fluoride alone over a 6-month period. Participants will be assigned to use either the test or control mouthrinse twice daily for six months. They will brush and rinse with their assigned product and visit the clinic every three months after the initial baseline visit for reassessment. The test mouthrinse includes 0.0553% sodium fluoride (250 ppm fluoride), amine, and 0.2% zinc lactate dihydrate, while the control mouthrinse contains only 0.0553% sodium fluoride (250 ppm fluoride). During the study, participants will undergo assessments of plaque levels and gum health using standard indices such as the Gingival Index and Plaque Index. The primary outcome measured is the improvement in gum health over six months, focusing on changes in the Gingival Index. Researchers will monitor participants' oral health status, adherence to the rinsing routine, and any safety concerns throughout the study duration.

Researchers are evaluating the effects of a cosmetic skin care product containing Mitopure on skin health and aging, focusing on wrinkles and skin hydration. The study targets men and women aged 45 to 65 with visible facial wrinkles and healthy skin in the test areas. The goal is to understand how this topical product influences skin hydration and wrinkle appearance over time. Participants will apply the cosmetic skin care product twice daily to half of their face, while the other half remains untreated. This approach allows for a direct comparison of treated versus untreated skin on the same individual. The treatment period lasts for 8 weeks during which the product's impact on skin hydration will be closely monitored. Throughout the study, participants will attend scheduled visits and undergo skin evaluations. Researchers will measure skin hydration after 8 weeks to assess the product's effects. The study also includes photographic documentation and requires adherence to the treatment schedule. Overall participation spans the treatment duration, focusing on skin changes and safety.