Les Abymes

Sepsis is a serious condition involving life-threatening organ dysfunction caused by an abnormal response to infection. It is a major global health issue, responsible for about one-fifth of deaths worldwide. This research aims to evaluate and compare how the NLRP3 inflammasome, a protein complex involved in inflammation, is activated in platelets among five groups of patients with bacterial and/or viral sepsis. These groups differ based on infection type and illness severity measured by the SOFA score to better understand platelets' role in the intense inflammatory reaction known as a cytokine storm. The study includes five groups: patients with leptospirosis, patients with bacterial infections including hospital-acquired infections, patients with viral infections, non-infected control patients, and patients infected with SARS-CoV-2. Each participant will have only one blood sample collected to assess the activation of the NLRP3 inflammasome in their platelets. This single sample approach simplifies participation and focuses on understanding the inflammasome's involvement in sepsis-related inflammation. Participants will be adults aged 18 years or older who agree to join the study or whose relatives or legal representatives provide consent. Researchers will measure the activation rate of the NLRP3 inflammasome in platelets as the primary outcome. The study seeks to clarify the contribution of platelet inflammasome activation to the immune response during sepsis, which may inform future treatments. There is no mention of additional study visits or long-term follow-up, with participation centered around this one-time blood collection.