Petit Bourg

Heart failure is a major health concern worldwide and is especially impactful in the Guadeloupe region, which has a high rate of heart failure deaths. This study evaluates the feasibility of robotic remote echocardiography integrated into a telemedicine system to improve heart failure management in the Guadeloupe archipelago, specifically comparing measurements of left ventricular ejection fraction (LVEF) between standard in-person echocardiography and two-dimensional remote echocardiography. Participants will undergo two types of echocardiography: in situ echocardiography performed by a cardiologist at Marie-Galante Hospital, and remote echocardiography conducted by a cardiologist from a private practice in Guadeloupe, with a nurse present at the patient's location. The study uses a randomized crossover design where patients receive both procedures in varying order. Cardiologists alternate between performing remote and in-person echocardiography to account for operator differences. Participants are involved in visits that include blood sampling and 24-hour ECG Holter monitoring. Researchers will measure the agreement of LVEF results between the two echocardiography techniques at the second visit, two weeks after inclusion. The study focuses on improving access to specialized heart failure care in a geographically isolated area and includes monitoring to ensure patient safety and data accuracy throughout the study period.

Cardiovascular disease is the leading cause of death in high-income countries, especially affecting African Americans who experience hypertension more frequently, earlier, and with more severity. This is linked to a higher risk of death and poorer hypertension control despite treatment. The Corin gene, which helps regulate blood pressure through natriuretic peptides, has a double polymorphism (I555/P568) found mostly in African descent populations and is associated with increased hypertension risk, heart conditions, and poorer response to treatment. This study investigates this gene variant in the Afro-Caribbean population of Guadeloupe, where hypertension prevalence is high and cardiovascular disease is a major cause of death. The study involves a diagnostic test to identify the double polymorphism (I555/P568) of the Corin gene. Participants are either cases with hypertension or controls without hypertension, matched by age and sex. Blood pressure measurements and medical history are used to classify participants. The research aims to understand the role of this gene variant in hypertension risk among people of African descent in Guadeloupe. Participants will provide consent and be assessed for hypertension status through blood pressure measurements and medical records. The study tracks the presence of the double polymorphism at day 15. Researchers will compare outcomes between hypertensive cases and controls to evaluate the genetic risk factor. The total involvement includes initial assessments, genetic testing, and follow-ups as needed to monitor blood pressure and related health information.