Petit Bourg

Heart failure is a major health concern, especially in the Guadeloupe region, which has one of the highest rates of heart failure deaths. Access to specialized cardiological care is limited on the island of Marie-Galante. This study evaluates the agreement of left ventricular ejection fraction LVEF measurements between standard in situ echocardiography EIS and two-dimensional remote echocardiography TER as part of a telemedicine system to improve heart failure management in this region. This is a prospective, randomized, interventional crossover study involving two cardiologists in private practice and one cardiologist at Marie-Galante Hospital. Participants undergo both EIS and TER in different orders to compare the techniques. During EIS, the cardiologist performs a standard ultrasound examination in person. For TER, a cardiologist remotely conducts the examination using robotic tele-echo-cardiography while communicating with the patient and a research nurse present at the hospital via videoconferencing. Participants have a baseline visit with blood tests and a 24-hour ECG Holter monitoring. Then at the second visit, two weeks later, the LVEF and other cardiac parameters are measured using both echocardiography techniques. Researchers assess agreement between the two methods, measure cardiac function and structure, record examination duration, and evaluate patient satisfaction. This study aims to explore the feasibility and integration of remote echocardiography within heart failure care over approximately two weeks, ensuring close monitoring of heart function and patient experience.

Researchers are investigating the role of a specific double polymorphism I555P568 of the Corin gene as a risk factor for arterial hypertension in people of African descent living in Guadeloupe. Hypertension and cardiovascular disease disproportionately affect this population, with higher severity and earlier onset. The Corin gene affects blood pressure regulation through its activation of natriuretic peptides, and this polymorphism is linked to poorer heart failure outcomes and hypertension in African Americans, but has not yet been studied in Guadeloupe. The study is interventional and involves two groups patients of Afro-Caribbean origin with hypertension and control participants of the same origin, sex, and similar age without hypertension. Hypertension diagnosis follows specific blood pressure thresholds measured in the doctors office, by self-measurement, or ambulatory monitoring. Participants will undergo diagnostic testing for the double polymorphism and various cardiovascular and metabolic assessments. During the study, participants will have several measurements taken including blood pressure, heart function tests, blood and urine analyses, and body measurements. The primary outcome is detection of the double polymorphism at day 15. Secondary outcomes include heart failure evaluation, kidney function, blood markers like natriuretic peptides and glucose, ECG measurements, and echocardiographic heart assessments at different time points. The study aims to better understand genetic contributions to hypertension and related conditions in this population.