Madhuban

Researchers are evaluating the effects of sodium hypochlorite and chlorhexidine as disinfectants on post-operative pain and the success of partial caries removal in mature permanent mandibular molars with deep carious lesions and moderate pulpitis. The study aims to compare the clinical and radiographic outcomes after partial caries removal using these disinfectants versus saline. The research focuses on improving treatment results for deep dental cavities while monitoring pain reduction after the procedure. Participants will undergo partial caries removal followed by cavity disinfection with either 2% chlorhexidine, 5.25% sodium hypochlorite, or saline control group. The study includes randomized allocation into one of three groups no disinfectant, sodium hypochlorite disinfection, or chlorhexidine disinfection. Treatment success will be assessed after 12 months, while post-operative pain will be monitored daily for one week. During the study, participants will receive clinical and radiographic evaluations at 12 months to measure the success of the treatment. Pain assessments will be conducted every 24 hours for seven days following the procedure. The research team will track both clinical and radiographic success criteria and monitor pain levels to evaluate the effectiveness of the disinfectants used. The total follow-up period for the primary outcomes is 12 months.

This research aims to evaluate the healing outcomes and quality of life in patients with apico-marginal defects and interproximal involvement related to endodontic and periapical diseases. The study compares the combined use of PRF-Medium plug and acellular chorionic membrane ACM with conventional endodontic surgery techniques. It focuses on patients with non-vital teeth suffering from chronic suppurative apical periodontitis and persistent defects, assessing whether this new combination improves recovery and patient wellbeing. Participants will undergo endodontic micro-surgery, where one group receives surgery with the placement of PRF-Medium plug and ACM membrane, while the comparison group undergoes surgery without these materials. The study involves two groups one treated with guided tissue regeneration GTR using the ACM membrane and PRF plug, and the other with surgery alone. The interventions are randomized, and the study employs triple masking to reduce bias. Throughout the 12 months following surgery, participants will be monitored with 2D periapical radiographs and 3D cone-beam computed tomography CBCT imaging to assess periapical healing. Quality of life assessments are also conducted from baseline to 12 months to evaluate patient outcomes. The study includes regular follow-ups to measure healing progress and patient-reported wellbeing, with the total participation duration being one year.