Madhuban

Study Design: Intervention Research Question : To investigate whether the use of 2% chlorhexidine and 5.25% sodium hypochlorite can improve the clinical and radiographic outcome after partial caries removal in deep carious lesion P (Population) - Mature Permanent Mandibular molars with deep carious lesion involving inner two third of dentine I (Intervention) - - Partial caries removal using 2% chlorhexidine/5.25% sodium hypochlorite as cavity disinfectant.. C (Comparison) - Partial caries removal using saline as cavity disinfectant. O (Outcome) - Assessment of clinical and radiographic success at 12 months follow up. -To assess incidence and reduction in pain post operatively at every 24 hours till 1 week.

Researchers are evaluating healing outcomes and quality of life in patients with periapical diseases involving apico-marginal defects and interproximal bone loss. This trial focuses on patients aged 16 years and older who have failed primary root canal treatment and persistent chronic suppurative apical periodontitis. The study compares a newer treatment approach using a combined platelet-rich fibrin (PRF) medium plug and acellular chorion membrane (ACM) with conventional endodontic surgery techniques. The study involves endodontic microsurgery performed on all participants. The test group receives surgery followed by placement of the PRF medium plug and ACM membrane, while the control group undergoes surgery without these materials. Imaging methods including 2D periapical radiographs and 3D cone beam computed tomography (CBCT) are used to assess healing over time. The primary outcome is periapical healing evaluated from baseline to 12 months post-surgery. Participants will be monitored through scheduled assessments including radiographic imaging to observe healing progress. Quality of life differences between groups will also be measured following surgery. The study includes patients classified as ASA-1 or ASA-2 for anesthesia risk and excludes those with certain dental complications or pregnancy. The total study duration includes follow-up evaluations up to one year after treatment.

Researchers are studying patients with walled-off pancreatic necrosis (WON), a serious condition that can develop after acute pancreatitis and is linked to a high risk of death. The study compares two approaches to treating WON: the standard endoscopic step-up approach and direct endoscopic necrosectomy (DEN) performed at the time of stent placement. Recent evidence suggests DEN might lead to faster resolution and fewer procedures, but this trial aims to confirm these findings by evaluating clinical outcomes. Participants undergo endoscopic drainage using lumen-apposing metal stents (LAMS). They are randomly assigned to receive either the step-up approach, where necrosectomy is performed after drainage if needed, or the direct approach, where necrosectomy is done immediately during stent placement. Necrosectomy involves removing dead pancreatic tissue using a gastroscope and specialized instruments. This international multicenter trial plans to enroll 108 patients over about three years. During the study, researchers will monitor for major complications or death within six months after randomization as the main outcome. They will also evaluate time to WON resolution, pancreatic function, need and number of necrosectomies, hospital and ICU stays, recurrence rates, and unplanned readmissions related to WON. Imaging, clinical assessments, and patient histories will be used to track progress and safety throughout the study period.