Kota Depok

Researchers are evaluating the efficacy and safety of BGM0504 compared with semaglutide as additional treatment to metformin in adults with type 2 diabetes in Indonesia. This Phase 3 trial aims to assess how well these treatments control blood sugar levels and their safety profiles in patients who have stable diabetes but still need better blood sugar management. Participants will receive either 5 mg or 10 mg of BGM0504 or 1 mg of semaglutide, all given by weekly subcutaneous injections. The study is randomized and open label, meaning participants are randomly assigned to one of these three groups and both participants and researchers know which treatment is given. The treatment period lasts 24 weeks, during which these drugs will be added to the participants ongoing metformin therapy. During the study, participants will have their blood sugar control measured through hemoglobin A1c HbA1c changes from baseline to week 24, along with body weight and fasting serum glucose levels. Assessments will also be made at week 12 for some outcomes. The trial involves safety monitoring and evaluates the percentage of participants reaching specific HbA1c target levels. The full participation duration is 24 weeks, with regular follow-up and assessments throughout this period.

Researchers are investigating how stigma and cultural factors in Indonesia influence the engagement of people living with HIV PLH with healthcare services and their health status. The study focuses on reducing HIV-related stigma, which is a major barrier to care engagement, especially in Muslim communities. Findings aim to inform strategies to improve HIV care retention both in Indonesia and in similar populations in the U.S. The study tests a culturally adapted stigma-reduction intervention based on Islamic teachings, delivered through a nurse-led, low-intensity, four-session program. Participants receive either this adapted intervention or usual care involving care coordination and support from public health nurses. Additional components include interviews and focus groups with Indonesians living with HIV to refine the intervention, though these groups are not followed for outcomes. Participants will attend study visits to assess changes in perceived and internal stigma, adherence to treatment, healthcare engagement measured by clinic visit attendance, and patient activation over 26 weeks. The study evaluates feasibility, acceptability, and preliminary effectiveness of the intervention while monitoring participants health and engagement in care. The total study duration includes baseline measurements and follow-up through the intervention period.

Researchers are evaluating the functional outcomes of patients who have experienced a rupture of the anterior cruciate ligament ACL and undergone reconstruction surgery using hamstring grafts. The study compares two surgical techniques the all-inside technique and the complete tibial tunnel technique. The hamstring graft, taken from the patients posterior thigh, replaces the torn ligament during reconstruction to restore knee stability. Patients will be randomly assigned to receive ACL reconstruction surgery using either the all-inside technique, which creates shorter bone sockets secured with adjustable-loop suspensory fixation, or the complete tibial tunnel technique, which involves full-length bone tunnels and fixation with a bio-interference screw and fixed-loop suspensory device. Both methods use hamstring grafts, and surgeries will be performed under double-blind conditions. Participants will be followed up at 3, 6, 9, and 12 months after surgery at an outpatient orthopedic clinic. Evaluations will include measurements of tibial translation, pain severity using a visual analogue scale, International Knee Documentation Committee IKDC scores, and Tegner-Lysholm knee scoring scales. The diameter of the hamstring graft will also be recorded during surgery. These assessments aim to compare knee function and recovery between the two surgical techniques over one year.

Researchers are evaluating a program aimed at reducing low back pain and improving physical and psychosocial health in office workers who frequently experience low back pain. The study focuses on how different combinations of exercise, posture education, and standing advice affect pain levels, lumbar posture, muscle function, ergonomics, stress, and quality of life. Participants are randomly assigned to one of three groups one group receives a supervised exercise program along with posture education and standing advice another group receives posture education and standing advice without exercise and the last group receives standing advice only. The exercise program includes progressive abdominal and lumbar strengthening exercises performed three times a week for 12 weeks, while the education and advice components are provided throughout the study period. During the 12-week study, participants will be assessed at the start and end for pain intensity, lumbar posture, core stability, flexibility, muscle fatigue and endurance, ergonomics, stress, and quality of life. Various tests and questionnaires, such as the Numeric Rating Scale for pain, Flexible Curve measurement, and Perceived Stress Scale, will be used. The study monitors progress and adherence to the program to understand which interventions offer the most benefit for office workers with low back pain.