Kota Depok

Researchers are evaluating the efficacy and safety of BGM0504 compared to semaglutide when added to metformin treatment in patients with type 2 diabetes in Indonesia. This Phase 3, randomized, open-label trial focuses on adults aged 18 to 75 years who have type 2 diabetes with specific blood sugar control levels. The study aims to see how these treatments affect blood sugar control measured by Hemoglobin A1c (HbA1c) over 24 weeks. Participants will receive either BGM0504 or semaglutide, both given by subcutaneous injection once weekly, in addition to their stable dose of metformin. The study compares these two drugs to assess their effects as add-ons rather than standalone treatments. The treatment period lasts 24 weeks, during which participants continue their current metformin dose. During the trial, participants will undergo regular monitoring, including blood tests to measure HbA1c changes from the start to week 24. Researchers will assess safety and treatment effects throughout the study. Participants are expected to maintain stable weight and metformin dosing. The total study duration for each participant is 24 weeks of treatment and observation.

Researchers are evaluating the functional outcomes of patients who have experienced an anterior cruciate ligament (ACL) rupture and undergo ACL reconstruction surgery using hamstring grafts. The study compares two surgical techniques: the all-inside technique and the complete tibial tunnel technique. The hamstring graft, taken from the patient's posterior thigh, replaces the torn ligament during reconstruction to restore knee stability. Participants will be randomly assigned to receive ACL reconstruction with either the all-inside technique, which uses retrograde drilling to create bone sockets and adjustable-loop suspensory fixation, or the complete tibial tunnel technique, which involves creating full-length bone tunnels and securing the graft with a bio-interference screw and fixed-loop suspensory device. Both surgical procedures use the patient's own hamstring graft as the tissue substitute. Throughout the study, patients will be evaluated before surgery and at 3, 6, 9, and 12 months after surgery. Assessments include measuring tibial translation, pain severity using visual analogue scales, International Knee Documentation Committee (IKDC) scores, Tegner-Lysholm knee scores, and intra-operative hamstring graft diameter. Follow-up visits include physical exams and clinical evaluations at the outpatient orthopedic clinic to monitor recovery and surgical outcomes.

Researchers are evaluating a program designed for office workers who experience low back pain. This program aims to reduce pain and improve physical and psychosocial outcomes such as lumbar posture, muscle function including core stability, flexibility, fatigue, and endurance, ergonomics, stress levels, and overall quality of life. The study compares different combinations of interventions to identify the most effective approach for office employees prone to low back pain. Participants will be assigned to one of three groups: Group 1 receives a physiotherapist-supervised exercise program targeting core stability and lumbar strength, combined with posture education and advice to take standing breaks; Group 2 receives posture education and standing advice without the exercise program; and Group 3 receives only standing advice. The exercise sessions are held three times per week for 12 weeks, lasting about 20 minutes each, with intensity increasing as participants progress. Education is provided at the start and reinforced throughout the 12 weeks, and standing advice encourages regular short standing breaks during work hours. During the study, participants will be monitored for changes in pain using a Numeric Rating Scale at baseline and after 12 weeks. Researchers will also assess lumbar posture, muscle physiology, ergonomics, stress, and quality of life. Participants' adherence to the exercise and standing advice will be tracked, and those who miss multiple sessions may be excluded. The total participation duration is 12 weeks, during which various physical and psychosocial outcomes will be measured to evaluate the effectiveness of the interventions.