Arese

Researchers are investigating how diets enriched with polyunsaturated fatty acids (PUFAs) from animal and plant sources affect chronic inflammation linked to cardiovascular disease risk. This study focuses on adults over 55 years old with moderate to high cardiovascular risk but without existing cardiovascular disease. The goal is to understand how lipid-driven inflammation can be managed through simple dietary changes, especially by comparing the impact of fish oil and Camelina Sativa oil supplements to a non-enriched diet. Participants will be randomly assigned to one of three groups: one receiving 4 grams of fish oil daily (containing DHA and EPA), another receiving 10 grams of Camelina Sativa oil daily (rich in ALA) plus vitamin E, and a control group receiving a regular diet with vitamin E. The supplementation period lasts 12 weeks, with oils administered as liquids before meals. Vitamin E is included to balance its levels across groups due to differing contents in the oils. During the study, participants will have clinical visits at the beginning and end of the 12 weeks, including blood sample collection for lipid and inflammation biomarker analysis, as well as measurements of heart rate, blood pressure, and waist circumference. They will also complete dietary questionnaires at these times. Researchers will assess changes in a lipid/inflammation risk score and participants' acceptance of the different PUFA supplements to develop practical tools for controlling cardiovascular inflammation through diet.