Crotone

Researchers are studying the effectiveness of the Deep Rectus Sheath Preperitoneal block in adults undergoing open or laparoscopic abdominal surgery. The goal is to see if this ultrasound-guided pain relief technique improves recovery and controls pain better than standard care or other nerve block methods such as TAP, ESP, or QL blocks. This observational clinical study is non-interventional and focuses on routine clinical care outcomes. Participants will receive pain management as per standard practice, which may include systemic analgesia alone, the Deep Rectus Sheath block combined with standard care, or other fascial plane blocks combined with standard care. Details such as the type of block, timing, technique, and local anesthetic dosages will be recorded. All patients will also receive multimodal pain relief following hospital protocols, with opioids reserved for rescue treatment. During the study, participants recovery quality will be measured using the Quality of Recovery-15 QoR-15 score at 24 hours after surgery. Pain levels at rest and with movement will be tracked up to 48 hours, along with analgesic use, time to first pain medication request, mobilization time, and any complications. Safety monitoring includes checking for block-related issues and neurological symptoms up to 7 days after surgery. The study is expected to complete within 12 months.

Researchers are evaluating rehabilitation methods for patients who have had a stroke within the past six months. The study aims to compare rehabilitation using Robot and Allied Digital Technologies RADTs with traditional rehabilitation, focusing on the recovery of daily living activities. This multicenter randomized controlled trial seeks to determine if rehabilitation with RADTs is not worse than traditional methods, while also exploring potential benefits, usability, and economic sustainability. Participants will be randomly assigned to one of two groups. The experimental group receives rehabilitation with RADTs, involving devices for upper and lower limb motor skills, gait, balance, and cognitive abilities, supervised by two physical therapists managing 4 to 6 patients. The control group undergoes traditional one-on-one rehabilitation targeting the same domains without robotic devices. Both groups complete 25 sessions of 45 minutes each, with inpatient treatments held five times a week for five weeks and outpatient treatments three times a week for about eight weeks. Throughout the study, participants will have various assessments including the modified Barthel Index to measure daily living activities, motor and sensory function tests, balance scales, cognitive tests, pain scales, and neurophysiological and biomarker evaluations. Follow-up evaluations will continue monthly for six months after treatment. Data are collected uniformly across centers to assess effectiveness, patient and caregiver acceptance, and economic impact of the rehabilitation methods.

This research aims to identify medium-term factors that influence recovery for patients with Severe Acquired Brain Injuries. It also seeks to develop a continuous system to assess the quality of care provided by rehabilitation units treating these patients. The study focuses on understanding key outcomes important to rehabilitation success. Data will be collected from each participating rehabilitation unit, including information about their structure and organization. Detailed patient data will be gathered upon admission to these units and then re-evaluated four months after their acute brain injury event. Statistical models will be used to predict the likelihood of achieving three key rehabilitation goals removal of tracheostomy tubes, trunk control, and full feeding by mouth. Participants will be adults admitted to these specialized rehabilitation units between July 2021 and December 2023. Patients admitted more than 14 weeks after their acute injury will not be included. Researchers will monitor patients for up to four months post-injury to evaluate the main outcomes. The study will help understand patient progress and care quality in these rehabilitation settings.

This research aims to understand how different locoregional anesthesia techniques affect recovery and pain control after hip replacement surgery. It focuses especially on the Quadro-Iliac Plane QIP block, a newer method used during hip arthroplasty. The study compares QIP to other common anesthesia methods to see if it improves patients postoperative recovery and pain management. Participants undergoing hip replacement as part of their usual care will receive one of several anesthesia techniques chosen by their anesthesiologist, which may include QIP block, fascia iliaca block, PENG block, or others. All blocks are performed using ultrasound guidance and standard safety procedures. The study is observational, so no treatments are assigned by the researchers. The planned participation period covers the hospital stay and up to 7 days after surgery for safety monitoring. Patients will be assessed for quality of recovery 24 hours after surgery using the QoR-15 score. Additional measures include pain levels at rest and during movement up to 48 hours, total pain medication used, time to first pain medication request, time to first mobilization, and any complications or side effects from anesthesia. Safety monitoring includes checking for immediate and delayed anesthesia-related issues up to one week post-surgery. The study expects to enroll 40 to 80 patients over about 18 months.

Researchers are evaluating the effectiveness and recovery outcomes of two combinations of locoregional anesthesia in adults over 18 years old undergoing unilateral total knee arthroplasty TKA under spinal anesthesia. The study compares the combination of adductor canal block ACB with sacral erector spinae plane ESP block to ACB combined with iPACK block. It aims to determine whether the ACB plus sacral ESP block provides effective pain relief and postoperative recovery. Participants receive spinal anesthesia and multimodal postoperative pain management, including paracetamol and rescue tramadol. The sacral ESP block is administered at the S2 level using ultrasound guidance and ropivacaine, while ACB and iPACK blocks follow standard protocols. Patients already receiving ACB plus sacral ESP block as part of their care will be observed for up to 48 hours after surgery. During the study, researchers will monitor recovery quality using the QoR-15 score at 24 hours, measure pain levels at rest and during movement over 48 hours, track time to first mobilization, analgesic consumption, and patient satisfaction. They will also watch for any complications related to the nerve blocks. The study lasts up to 30 months, and all data collection respects patient privacy and ethical standards.