Ortona

This research evaluates a surgical approach for women with luminal breast cancer who have limited axillary lymph node involvement detected by ultrasound and confirmed by biopsy. The study aims to avoid extensive axillary lymph node dissection (ALND) in patients undergoing upfront surgery without neoadjuvant treatment, reducing unnecessary surgery while managing confirmed nodal metastases. The focus is on patients with one or two suspicious lymph nodes and positive cytology or histology. Participants will undergo upfront targeted axillary dissection (UTAD), where marked lymph nodes and sentinel lymph nodes are removed and examined. ALND will only be performed if three or more sentinel lymph nodes are positive, with at least one showing macrometastasis. This approach follows the latest NCCN guidelines and aims to minimize overtreatment during surgery. Throughout the study, patients will be assessed during surgery and followed up to monitor outcomes such as successful retrieval of the marked lymph node and prevention of ALND. The study includes adult women aged 18 to 90 who can complete study procedures and follow-up. Researchers will evaluate surgical results and patient status over the entire study period to ensure safety and effectiveness of the procedure.