Pavullo Nel Frignano

This research focuses on Parkinson's disease (PD) patients who experience disabling postural abnormalities, specifically Pisa Syndrome (PS) and camptocormia. These conditions involve abnormal trunk flexions that worsen during standing or walking and improve when lying down. Patients with these postural disorders often face increased motor asymmetry, back pain, balance problems, and a lower quality of life, and current treatments like medication and physiotherapy provide only limited and short-term relief. The study evaluates the use of an AI-based home rehabilitation system called the Kemtai platform as a complementary treatment following 4 to 8 weeks of in-hospital neurorehabilitation. This platform uses video-based AI to provide personalized exercise programs with real-time visual feedback to help patients improve their posture from home. The goal is to see if this technology can sustain and enhance the benefits gained during inpatient rehabilitation. Participants will be assessed for usability and safety of the AI system after 6 to 8 weeks of home use. Researchers will collect both qualitative data on user satisfaction and quantitative measures such as trunk angles and mobility scores. The study aims to explore whether this AI-guided exercise can maintain improvements in posture, mobility, and quality of life over the medium term, supporting greater independence in daily life.

Researchers are studying how best to treat trauma patients with low blood pressure (hypotension) before they reach the hospital, focusing on how different prehospital care methods affect recovery and survival in the hospital. The study addresses gaps in evidence about treatments like prehospital blood transfusions and resuscitative endovascular balloon occlusion of the aorta (REBOA). It also examines the variability in emergency medical services across Italy, especially in helicopter emergency medical services (HEMS), and how these differences might impact patient outcomes. Participants will receive various treatments during prehospital care, including drugs such as antifibrinolytics, analgesics, sedatives, and neuromuscular blockers; devices like REBOA and extended focused assessment sonography for trauma (eFAST); blood transfusions; and different management strategies like "stay and play" versus "scoop and run." Each patient’s demographic information, trauma type, injury severity, and therapies used will be recorded for analysis. Throughout the study, researchers will collect data on hospital outcomes such as the need for blood transfusions, blood gas parameters, length of hospital and ICU stays, use of invasive ventilation and kidney support therapies, recovery progress, and mortality within 30 days. This comprehensive monitoring aims to identify factors during prehospital care that relate to survival and recovery after trauma, with participant involvement lasting through hospitalization and follow-up for 30-day mortality.