Piancavallo

Researchers are examining treatments for women with obesity and Binge Eating Disorder (BED) who have experienced traumatic events. This study compares Eye Movement Desensitization and Reprocessing (EMDR), a trauma-focused therapy, to Cognitive Behavioral Therapy (CBT), the usual treatment for BED. The trial aims to see if a 4-week EMDR intervention reduces binge eating, emotional eating, psychological distress, trauma-related symptoms, and improves emotion regulation more effectively than CBT in a residential rehabilitation setting. Participants receive either EMDR or CBT during a 4-week inpatient rehabilitation program. EMDR focuses on processing traumatic memories to relieve distress and improve psychological symptoms, while CBT addresses eating disorder behaviors, body image, and emotional reactions to support healthy eating patterns and weight management. The trial is conducted at a specialized clinical center in Italy, with evaluations before and after treatment. During the study, participants complete questionnaires to assess distress from trauma, binge eating, emotional eating, psychological distress, and emotion regulation over 4 weeks. Researchers monitor symptoms and treatment effects throughout the inpatient stay. The study collects data securely and follows participants closely to evaluate the impact of both therapies on their eating disorder and trauma symptoms.

This research aims to evaluate various aspects of health in adults with Obstructive Sleep Apnea Syndrome (OSAS) before and after three weeks of ventilotherapy. The study focuses on changes in cognitive performance, blood markers linked to neurodegeneration, and psychosocial wellbeing. It emphasizes the importance of a multidisciplinary approach to treating OSAS, which may improve treatment outcomes and patient satisfaction. Participants will receive ventilotherapy using a continuous positive airway pressure (CPAP) device during sleep for three weeks. The treatment is designed to support breathing, restore brain oxygenation, and improve rest. Evaluations are conducted both before starting ventilotherapy and after the three-week treatment period. During the study, participants will undergo neuropsychological assessments, blood sampling to measure biomarkers related to neurodegeneration, and complete self-reported questionnaires about their psychosocial health. Researchers will measure overall cognitive function, selective attention, memory, learning, visuo-spatial skills, inhibition, planning, and decision making at baseline and after treatment to understand the effects of ventilotherapy on these areas.

Researchers are conducting an international, multicenter, prospective, non-interventional observational registry to study patients with X-Linked Hypophosphatemia (XLH). The goal is to gather data to better understand the treatment approaches, disease progression, and long-term outcomes for both adults and children with XLH. This registry also supports a Post-Authorisation Safety Study (PASS) requested by the European Medicines Agency to monitor safety concerns related to burosumab treatment. Patients of all ages and genders with XLH can join the registry, regardless of whether they are currently receiving treatment. The registry collects data through a web-based system, including baseline, retrospective, and ongoing information from regular visits. Physicians will update patient data approximately every 12 months or more frequently if part of standard care, without any additional interventions required beyond routine clinical practice. Participants or their legal representatives provide informed consent, with assent sought from children when appropriate. Data collection involves recording clinical, radiological, biochemical, and genetic information supporting the diagnosis. Safety monitoring includes tracking treatment-related adverse events over a 10-year period. The registry follows patients over time, capturing comprehensive information to improve understanding of XLH and its management.

Researchers are investigating the role of interoception—the ability to perceive internal body signals—and its connection to obesity. The study explores how difficulties in sensing and integrating internal bodily cues with external information might relate to high Body Mass Index (BMI) and eating behaviors. Understanding these relationships at perceptual, cognitive, and emotional levels could provide insights into obesity and its effects on health and emotional functioning. Participants will engage in a combined sensory task called the crossmodal dual-task. This involves two main activities: a visual task where participants monitor images on a screen and respond quickly to specific targets that include either food or non-food stimuli, and an interoceptive task where they listen to their heartbeat sounds via headphones and assess timing differences between their heartbeat and auditory cues. Participants' reaction times and accuracy in the visual task, as well as their judgments in the heartbeat task, will be recorded. During the experiment, researchers will measure participants' visual detection speed and interoceptive judgment abilities. These assessments aim to evaluate how well participants perceive and integrate internal and external signals. The study focuses on female adults with obesity receiving rehabilitative treatment, and it excludes those with neurological, developmental, motor, sensory, or psychiatric conditions. The results may help clarify how interoceptive processes contribute to obesity and related behaviors.