Piancavallo

Researchers are evaluating multiple aspects of health in patients with Obstructive Sleep Apnea Syndrome OSAS, focusing on changes before and after three weeks of ventilotherapy. The study aims to understand how ventilotherapy may affect cognitive performance, blood markers linked to neurodegeneration, and psychosocial wellbeing in these patients. This observational research highlights the importance of a holistic approach to OSAS treatment, as cognitive and psychosocial difficulties are common but not well understood. Participants will undergo ventilotherapy using a breathing support device during sleep for three weeks. The study compares patients health before and after this treatment period, examining various cognitive functions such as memory, attention, decision making, and planning. Blood samples will be collected to assess biomarkers related to neurodegeneration, and patients will complete self-reported questionnaires on psychosocial wellbeing and quality of life. During the study, patients will complete neuropsychological assessments, blood sampling, and psychosocial questionnaires at the start and after three weeks of ventilotherapy. Researchers will measure cognitive functioning, selective attention, memory, visuo-spatial abilities, inhibition, planning, decision making, neurodegeneration biomarkers, psychosocial wellbeing, and quality of life. The study is expected to provide comprehensive insights into the broader effects of ventilotherapy over this three-week period.

Researchers are conducting an international, multicenter, prospective observational registry to study patients with X-Linked Hypophosphatemia XLH. This registry aims to collect detailed data on the natural history, treatment patterns, progression, and long-term outcomes of XLH in both adults and children. The study includes patients regardless of whether they are currently receiving treatment for XLH. Participants will be enrolled in a non-interventional setting without any additional treatments or procedures beyond their standard clinical care. Data will be collected retrospectively and prospectively using a web-based system. Physicians will update patient information during routine visits, with reminders to update data approximately every 12 months. Some sites may also participate in a post-authorization safety study PASS to monitor treatment-related adverse events. Participants will provide informed consent or assent according to age and national guidelines. The study team will collect baseline and ongoing clinical information, including treatment details and adverse events, over a period extending to 10 years. No fixed follow-up schedule is required, but data updates align with patients usual healthcare visits. Researchers will review adverse events related to treatment as a primary outcome measure throughout the study period.

Researchers are exploring how the bodys ability to sense internal signals interoception and combine them with external information affects obesity and related eating behaviors. This study focuses on understanding the links between interoceptive signals, body mass index BMI, and reactions to external food cues in women with obesity. The goal is to clarify how these internal and external processes relate to cognitive, emotional, and health aspects in obesity. The study involves two groups of right-handed women aged 18 to 55 those diagnosed with obesity undergoing rehabilitation treatment and healthy controls without eating disorders. Participants perform a combined sensory task where they respond to visual food and non-food stimuli on a computer screen while simultaneously monitoring their heartbeat through headphones. Reaction times, accuracy in visual detection, and judgments about heartbeat timing are recorded to assess interoceptive and visual processing. During the study, participants are evaluated through these dual tasks measuring visual detection speed and accuracy along with interoceptive judgment. The study collects data at the time of testing to understand how sensory processing relates to obesity. This observational study is sponsored by Istituto Auxologico Italiano and includes healthy volunteers, with total participation lasting for the duration of the single testing session.