Scorrano

Researchers are evaluating delivery outcomes using the Artificial Intelligence Dystocia Algorithm AIDA method, which analyzes intrapartum ultrasound parameters such as Angle of Progression, Asynclitism degree, fetal head-symphysis distance, and midline angle. The study focuses on both eutocic normal and dystocic difficult labor, aiming to assess labor progress and predict outcomes including neonatal Apgar scores at 1 and 5 minutes. This approach addresses challenges in fetal head positioning that affect labor progression and delivery decisions. Participants will be monitored during labor using intrapartum ultrasound with clinical and obstetric parameters analyzed by the AIDA method. The AIDA system classifies labor into five categories based on these geometric parameters, helping to predict whether cesarean delivery will be necessary. This observational study follows women through labor and after birth, using artificial intelligence combined with physician decision support to evaluate labor progress and outcomes. During the study, women will undergo ultrasound monitoring and have their labor progress tracked by the AIDA analysis. Researchers will measure labor outcomes and neonatal health indicators over one year. Data collected includes ultrasound parameters, clinical assessments, and delivery results. The study aims to improve understanding of labor complications and support clinical decisions by providing detailed evaluations of fetal positioning and labor progression.

This research aims to study the epidemiology of invasive bacterial diseases caused by Streptococcus pneumoniae pneumococcus, Neisseria meningitidis meningococcus, and Haemophilus influenzae hemophilus. These infections can cause severe illness and serious complications. The study focuses on monitoring these infections to guide public health efforts, evaluate vaccine impacts, and plan prevention and treatment strategies by identifying circulating strains and assessing vaccine failures. The study uses molecular diagnostic testing to identify these bacteria from blood samples, even when traditional culture methods may fail due to prior antibiotic use or sample handling issues. Pediatric and adult patients diagnosed with invasive bacterial diseases caused by these pathogens are included. This approach enables more accurate detection and characterization of the bacteria. Participants diagnosed with these invasive bacterial infections will have their samples analyzed using molecular methods. Researchers will monitor the incidence rates of these infections in children, the distribution of bacterial types, and the proportion of cases preventable by vaccination. The study will also assess vaccine failure rates. The average study duration for outcome measurement is about one year, supporting improved surveillance and public health interventions.

Researchers are evaluating the effect of a combination of natural molecules including Epigallocatechin gallate, Vitamin D, D-chiro-inositol, and Vitamin B6 on the size of uterine fibroids in women aged 30 to 40 years. The study aims to compare changes in fibroid volume and diameter over a three-month period between women receiving the active supplement and those receiving a placebo. This trial is randomized and uses quadruple masking to ensure unbiased results. Participants will be randomly assigned to one of two groups one group will take two tablets daily for three months, each containing 150 mg of Epigallocatechin gallate, 25 mg of D-chiro-inositol, 5 mg of Vitamin B6, and 25 mcg of Vitamin D the other group will receive a placebo made of maltodextrins. The treatment period lasts three months with evaluations conducted at the start and after the treatment period. During the study, women will be assessed for fibroid diameter and volume, need for surgery, levels of pVEGF-R, and markers of cellular proliferation at baseline and after three months. Researchers will monitor these outcomes to understand the treatments impact. The total study duration for participants is three months, during which their symptoms like menometrorrhagia or pelvic pain will also be considered.