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Researchers are evaluating the DESC-Glove, a special instrumented glove designed to aid sensorimotor rehabilitation in people recovering from a stroke. The study aims to assess the gloves technical function, safety, and reliability during rehabilitation. It also explores how usable and acceptable the device is for both patients and healthcare professionals, as well as its short-term effects on hand movement and dexterity. The study has two phases. Phase 1 tests the DESC-Glove on 5 patients through four treatment sessions involving fine and gross motor exercises for the hand and upper limb. Patients wear the glove on their affected hand and receive synchronized vibrational feedback. Phase 2 is a larger randomized trial with 42 participants divided into three groups one uses the DESC-Glove with vibration, another uses it without vibration sham, and the last receives conventional hand rehabilitation without the glove. Treatments consist of two 20-minute sessions per day, three times a week, over four weeks. Participants will undergo various assessments including tests of hand dexterity and arm function before and after the treatment period. Researchers will monitor device malfunctions and dropouts related to the device after each session. Questionnaires will collect feedback on the gloves usability and acceptance. The study includes weekly and final evaluations to measure changes in sensorimotor performance and manual dexterity, providing comprehensive data on the gloves impact during post-stroke rehabilitation.

Researchers are evaluating rehabilitation methods for patients who have had a stroke within the past six months. The study aims to compare rehabilitation using Robot and Allied Digital Technologies RADTs with traditional rehabilitation, focusing on the recovery of daily living activities. This multicenter randomized controlled trial seeks to determine if rehabilitation with RADTs is not worse than traditional methods, while also exploring potential benefits, usability, and economic sustainability. Participants will be randomly assigned to one of two groups. The experimental group receives rehabilitation with RADTs, involving devices for upper and lower limb motor skills, gait, balance, and cognitive abilities, supervised by two physical therapists managing 4 to 6 patients. The control group undergoes traditional one-on-one rehabilitation targeting the same domains without robotic devices. Both groups complete 25 sessions of 45 minutes each, with inpatient treatments held five times a week for five weeks and outpatient treatments three times a week for about eight weeks. Throughout the study, participants will have various assessments including the modified Barthel Index to measure daily living activities, motor and sensory function tests, balance scales, cognitive tests, pain scales, and neurophysiological and biomarker evaluations. Follow-up evaluations will continue monthly for six months after treatment. Data are collected uniformly across centers to assess effectiveness, patient and caregiver acceptance, and economic impact of the rehabilitation methods.

Researchers are evaluating the effectiveness of a home-based telerehabilitation program using digital tools compared to a traditional educational program for patients with disabilities following a stroke. The study focuses on whether this digital neuromotor and cognitive rehabilitation improves static and dynamic balance better than usual care. This multicenter, randomized, controlled trial aims to assess improvements measured by the Berg Balance Scale in patients with subacute and chronic stroke. Participants will be randomly assigned to one of two groups. The experimental group will follow a 6-week remote telerehabilitation program involving task-oriented balance exercises, performed both standing and seated, with complexity tailored to individual progress. One session per week is supervised remotely by a therapist, while other sessions are completed independently. The control group will follow a 6-week self-guided educational program supported by printed materials, with weekly phone calls and an activity diary to monitor progress. During the study, participants will undergo assessments at the start and within seven days after completing the 6-week program. These include balance tests, motor and sensory function evaluations, cognitive assessments, pain scales, and functional mobility measures. Data will be collected using a standardized platform, and the researchers will monitor adherence, acceptability, usability, and economic sustainability of the digital intervention. The total participation lasts for six weeks of treatment plus assessments.