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Researchers are evaluating the effectiveness of two different physical therapy timing approaches for people with end-stage renal disease (ESRD) who are undergoing hemodialysis. The study compares exercises performed during dialysis sessions (intradialytic) versus exercises done before dialysis sessions (pre-dialysis). The goal is to find which timing better improves physical function, quality of life, and biochemical health markers like hemoglobin and electrolyte levels. Participants will follow a structured physical therapy program twice a week for 12 weeks. This program includes warm-up, strengthening, balance, and stretching exercises delivered either during or before their dialysis sessions. Both groups will receive education on exercise benefits and safety before starting. The study is a randomized controlled trial conducted at a dialysis center in Kuwait. Throughout the study, participants' physical abilities will be measured using tests like the Six-Minute Walk Test and Five Times Sit-to-Stand Test at baseline, every 4 weeks during the 3-month intervention, and again at a 6-month follow-up. Quality of life will be assessed with a kidney disease questionnaire at the same times. Researchers will also monitor blood markers such as hemoglobin and electrolytes. This detailed monitoring aims to understand how physical therapy timing affects health and well-being over time.