Actively Recruiting
A Comparative Study of Intradialytic Versus Pre-Dialysis Physical Therapy Interventions in Individuals Undergoing Hemodialysis: A Randomized Controlled Trial
Led by Mohammad Arian · Updated on 2026-01-22
72
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare two timings of physical therapy for adults with end-stage renal disease (ESRD) who are undergoing hemodialysis. The study evaluates whether exercising during dialysis sessions or before dialysis leads to better improvements in physical function, quality of life, and laboratory measures such as hemoglobin and electrolyte levels. A total of 72 adult participants will take part in this randomized controlled trial to help determine the best approach to physical therapy in this population. Participants will be randomly assigned to one of two groups. One group will perform supervised physical therapy exercises during their dialysis sessions twice weekly for 12 weeks, while the other group will perform the same exercises before their dialysis sessions on the same schedule. Each session lasts about 30 minutes and includes warm-up, resistance training, and cool-down. Both groups will first receive standardized education about the benefits and safety of exercise before starting the intervention. Throughout the study, participants will undergo assessments including the Six-Minute Walk Test, Five Times Sit-to-Stand Test, and quality of life questionnaires at baseline, every four weeks during the 12-week intervention, and at a 6-month follow-up. Blood tests to measure hemoglobin and electrolyte levels will be done at baseline and at 4, 8, and 12 weeks. The study monitors these outcomes to evaluate the effects of exercise timing on health and well-being for individuals on hemodialysis.
CONDITIONS
Brief Title
A Comparative Study of Intradialytic vs. Pre-Dialysis Physical Therapy Interventions in Individuals Undergoing Hemodialysis: A Randomized Controlled Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged between 21 and 65 years
- Diagnosed with end-stage renal disease (ESRD)
- Undergoing maintenance hemodialysis for at least 3 months
- Medically stable and cleared by the nephrologist to participate in moderate physical exercise
- Able to understand and follow verbal instructions and provide informed consent
You will not qualify if you...
- Uncontrolled hypertension, recent myocardial infarction, or unstable angina
- Severe musculoskeletal, neurological, or cardiovascular disorders that limit physical activity
- Active infection, fever, or open wounds
- Recent hospitalization within the past month
- Participation in any other structured exercise program within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for eligibility assessment and informed consent
Duration - 12 weeks
Participants perform supervised physical therapy exercises either during or before hemodialysis sessions twice weekly, including warm-up, strengthening, balance, and stretching exercises.
Twice weekly sessions for 12 weeks during or before dialysis
Duration - 1 day (6-month follow-up visit)
Participants are assessed at 6 months after the intervention to evaluate long-term effects of the physical therapy program.
1 follow-up visit (in-person) at 6 months post-intervention
Trial Site Locations
Total: 1 location
1
Mubarak Al-Abdullah Al-Jaber Al-Sabah Dialysis Center
Hawalli, Kuwait
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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