Marrakech

Researchers are evaluating how an educational program affects sexual function and treatment adherence in women with breast cancer treated at a medical oncology department in Marrakech. This study focuses on women diagnosed with breast cancer who are receiving oral anticancer treatments and aims to understand the impact of education on their health behaviors and well-being. Participants will take part in a structured therapeutic education program consisting of two face-to-face sessions, each lasting two hours, led by a trained midwife specializing in oncology care. The sessions cover breast cancer, treatment options and side effects, sexual health, and the importance of following prescribed treatments. After these sessions, participants will receive ongoing support and reminders through WhatsApp to reinforce key messages. During the study, women will complete questionnaires assessing sexual function and treatment adherence before the education program and again two months afterward to measure any changes. The study involves interviews and medical record reviews to collect clinical data. Researchers will analyze the results to evaluate the programs effects, and participants have the right to withdraw at any time. The total participation duration includes the education sessions and follow-up assessments over two months.

Researchers are assessing a specific blood gas ratio, the PvCO2-PaCO2CaO2-CvO2, as a potential marker of anaerobic metabolism in patients experiencing acute circulatory failure caused by septic shock. The study compares the changes in this ratio to the classic marker of anaerobic metabolism, arterial lactate, during the early phase of septic shock. This observational research is conducted to better understand the prognostic value of this ratio in critical illness. Adult patients diagnosed with septic shock, characterized by persistent low blood pressure requiring vasopressors and elevated lactate levels despite adequate fluid treatment, will be enrolled. Participants will undergo serial blood tests to measure arterial and venous blood gases and arterial lactate at several time points baseline H0, 2 hours, 6 hours, 12 hours, and 24 hours after inclusion. The study involves calculating the PvCO2-PaCO2CaO2-CvO2 ratio using specific formulas based on oxygen content in the blood. Participants will be closely monitored through these blood assessments to track the kinetics of the studied ratio and compare it to arterial lactate levels. The main outcome measured is the prognostic value of the PvCO2-PaCO2CaO2-CvO2 ratio over the first 24 hours following study inclusion. This monitoring helps researchers understand how this ratio behaves during the early septic shock phase and its potential to guide patient care. The study is sponsored by Avicenna Military Hospital and will continue until June 2026.