Marrakech

Researchers are evaluating the impact of an educational program on sexual function and treatment adherence in women diagnosed with breast cancer. The study is conducted at the medical oncology department of Ibn Tofail Hospital, part of the Mohammed VI University Hospital Center in Marrakech. It aims to understand how a structured education intervention might influence these important aspects of care among women receiving oral anticancer therapy. The intervention involves two in-person educational sessions, each lasting two hours, led by a midwife trained in oncology and palliative care. These sessions cover breast cancer information, treatments and side effects, effects on sexual function, and strategies to maintain treatment adherence. After the sessions, participants receive supportive follow-up through WhatsApp to reinforce key messages and address concerns. The program content is tailored to meet participants' individual needs and health literacy. Participants will complete validated questionnaires assessing sexual function and therapeutic adherence before the education sessions and again two months after completing the intervention. Sociodemographic and clinical information will be collected through interviews and medical record reviews. Data analysis will use SPSS software, applying non-parametric tests when needed. The study emphasizes ethical standards, including informed consent and the right to withdraw at any time.

Researchers are studying the ratio of venous-arterial carbon dioxide partial pressure difference to arteriovenous oxygen content difference (PvCO2-PaCO2/CaO2-CvO2) as a potential marker of anaerobic metabolism in patients with acute circulatory failure, specifically in septic shock. The study aims to evaluate the prognostic value and early kinetics of this ratio compared to the traditional marker, arterial lactate, during the initial phase of septic shock. Patients diagnosed with septic shock will have serial measurements taken of arterial and venous blood gas analyses and arterial lactate levels. These measurements will occur at defined time points: baseline (H0), 2 hours (H2), 6 hours (H6), 12 hours (H12), and 24 hours (H24). The PvCO2-PaCO2/CaO2-CvO2 ratio will be calculated using specific formulas for arterial and venous oxygen content. This procedure is used as a diagnostic test to monitor changes over the first day of septic shock. During the study, participants will undergo multiple blood tests at the scheduled time points to measure gas levels and lactate. Researchers will observe how the PvCO2-PaCO2/CaO2-CvO2 ratio changes over time and compare it to arterial lactate levels to assess its value as a prognostic marker. The study involves close monitoring within the first 24 hours after septic shock diagnosis to understand early metabolic changes.