Invercargill

Researchers are conducting the EXTUBE study, an international and multicenter observational research project, to understand the occurrence, risk factors, and outcomes of complications related to extubation after general anesthesia or critical illness. Extubation is a common but potentially risky procedure performed worldwide, with serious complications such as decreased oxygen delivery, cardiac arrest, brain damage, or death occurring in some cases. This study aims to fill gaps in knowledge due to limited and inconsistent past data, addressing the frequency and nature of these complications and adherence to best practices. The study observes adult patients undergoing extubation of an endotracheal tube in various settings including operating rooms, out-of-OR anesthesia locations, and intensive care units. It collects detailed data during the immediate period following extubation, focusing on complications occurring within 60 minutes and up to seven days after the procedure. No interventions or treatments are assigned instead, clinical practices and outcomes are monitored to identify risk factors and guideline adherence. Participants will be followed closely around the time of their extubation, with data collected on immediate and short-term complications such as severe hypoxemia, cardiac arrest, airway management needs, and reintubation. Researchers will evaluate complications, including airway injuries, cardiovascular events, and mortality until hospital discharge. The study involves careful documentation of clinical events and patient outcomes without altering standard care. Participants involvement duration will vary depending on their hospital stay and timing of extubation-related events.