Makurdi

Benign prostatic hyperplasia BPH is a common condition affecting many men as they age, often leading to lower urinary tract symptoms LUTS. Due to a growing and aging population, the number of men diagnosed with BPH continues to rise, making treatment for this condition one of the most performed surgical procedures in urology. This research aims to establish a global, ongoing registry that collects detailed demographic and clinical data on men undergoing medical or surgical treatments for BPH to better understand treatment patterns and outcomes worldwide. The registry records information from men aged 18 and older with a primary diagnosis of BPH and LUTS who are receiving either medication or surgical intervention. Data collected includes baseline demographics, peri-operative details, and follow-up outcomes with no actual interventions performed by the registry team. The study uses validated patient-reported outcome measures like the International Prostate Symptom Score IPSS, Sexual Health Inventory for Men SHIM, and Male Sexual Health Questionnaire for Ejaculatory Dysfunction MSHQ-EjD, along with clinical data such as quality of life, urine flow rates, prostate-specific antigen levels, and complications related to treatment. Participants provide data over a period of three years with ongoing follow-up and no fixed end date, allowing for long-term observation of treatment effectiveness and safety. The registry also ensures data security and quality through encryption, user access controls, and regular audits. Researchers will analyze outcomes including symptom scores, quality of life, post-void residual urine, and complications like incontinence, bleeding, urinary tract infections, and erectile dysfunction, aiming to inform future BPH management and research.

Researchers are evaluating two combination interventions aimed at addressing adolescent HIV infection among youth aged 15 to 24 in Nigeria. These parallel 48-week hybrid effectiveness and implementation trials focus on improving HIV case finding and HIV treatment outcomes, particularly among young men who have sex with men YMSM. The study aims to identify youth living with HIV, link them to care, and support medication adherence and viral suppression in newly diagnosed individuals. The first intervention is a single-arm trial focusing on HIV case finding and linkage to care, using peer navigation and motivational interviewing to encourage HIV testing and pre-exposure prophylaxis PrEP uptake among those who test negative. The second is a randomized controlled trial comparing a combination HIV treatment intervention involving peer support and SMS reminders to standard care adherence support among youth newly starting antiretroviral therapy ART. Participants will be engaged over 48 weeks, with assessments including HIV testing, linkage to care, ART adherence, and viral load monitoring. Researchers will collect data on intervention effectiveness and implementation success, measuring outcomes such as HIV-positive serostatus, viral suppression, linkage to HIV care, and PrEP initiation. The study includes behavioral components like social media outreach and peer navigation to promote testing and treatment adherence.